Step 3: Polishing
Save up to 70% Processing Time and Work Space with Ready-to-Use Membrane Chromatography
Fast and Efficient Contaminant Removal with Sartobind®
Anion Exchange Sartobind® Flow Through Membrane Chromatography delivers over 70% less processing time in polishing. Membrane Chromatography eliminates packing and cleaning validation, and has flow rates up to 20 times faster than traditional column chromatography. Use Sartobind® STIC, a salt tolerant Membrane Adsorber, to eliminate buffer dilution requirements and significantly reduce your process volumes.
Loading >10 kg mAb per L Membrane
Sartobind membrane adsorbers have about 40 to 200 times more polishing capacity than traditional chromatography columns and can be run at much higher flow rates during effective impurity removal steps:
- Virus clearance > 6 log
- DNA below detection limit
- Host cell protein removal > 99 %
- Endotoxin removal > 5 log
Boosting mAb Processes
Hydrophobic interaction chromatography by membranes allows for fast and effective aggregate removal resulting in 100% monomeric mAb in flow through mode.
The Column Guard
Platform Your Downstream 0.2 μm Filtration with Sartopore® 2 XLG
Choose Sartopore® 2 XLG 0.8/0.2 μm for sterile filtration of downstream intermediates and protection of chromatography columns with demonstrated high capacity over numerous molecules. Its fully-scalable portfolio with standard offering as Filter Transfer Sets enables very easy integration into modern single-use processes.