Step 4: Virus Filtration
Highest Safety for Your mAb Process with Virus Retentive Filtration
Reliable Retention Under All Circumstances
Virus filtration is the state of the art technology for virus clearance providing robust and stable virus retention. The unique Sartorius high performing membranes are efficiently removing viruses even under challenging process conditions like e.g. pressure interruptions. Expect robust and constant performance in virus clearance with up to five times shorter process time. Find the best performing membrane for your process within our three different virus retentive membranes. In combination with our membrane chromatography technology and FlexAct® VI for low pH inactivation your orthogonal virus clearance concept will be easily fullfield.
Optimize Your Operation with FlexAct®
Fast Track Single-Use Implementation
The FlexAct® central operating unit is interchangeable throughout multiple process steps. Reduce the footprint of your virus filtration step by implementing the FlexAct® single-use system with the compact Virosart® HF gamma sterilized filter. This combination makes it ideal for use in multi-product facilities providing versatility, cost reduction, and up to 5x shorter processing time as you do not require a separate unit for each process step in your downstream mAb processing.
20% Higher Cost Efficiency for your Virus Filtration Step with Virosart® HF
Virosart® HF is Cost Efficient with High Capacity and Reduced Flushing Volumes
Highest cost efficiency is achieved with up to 80 % reduced flushing volumes and 3x higher capacity at high flow rates. The compact capsule design avoids costly stainless steel filtration systems and increases flexibility by adjusting the filter area to changing process demands. The high filter packing density enables a substantial (>90%) footprint reduction. Virosart® HF is the only virus retentive filter sterilisable by gamma irradiation which makes it optimal for fully single use applications.
Virosart® Max Adsorptive Virus Pre-Filter
Maximize your Virus Filter Capacity
The Virosart® Max protects all available virus retentive filters with a performance independent from process conditions. Final virus filters could increase significantly their total throughput and reduce total virus filtration costs.