Virus Retention for Cell Culture Media
Virus-retentive filtration is a highly efficient method for viral risk mitigation of cell culture media. This filter targets both non-enveloped viruses, such as MVM and vesivirus, and large enveloped viruses, such as MuLV. Virosart® Media is especially designed for virus filtration of chemically defined cell culture media.
A New Virus Risk Mitigation Strategy
A new strategy is the removal of viruses before the bioreactor already after media preparation to prevent potential contaminations of the bioreactor. Virus filtration is a proven and well established technology within the market to remove all kind of viruses (> 20 nm range).
Our Solution: Virosart® Media
Virosart® Media is a virus retentive filter specially developed for upstream applications. The newly developed media filter overcomes today’s bottlenecks of virus filters originally developed for downstream applications and provides a cost effective solution in upstream with highest filter capacity for cell culture media.
Virus risk mitigation in media preparation of:
- Chemically defined cell culture media
- Addition of media supplement such as CaCl2
- Powder as well as liquid media
Highest safety for the bioreactor:
- ≥ 4 LRV for small non-enveloped viruses
- ≥ 6 LRV for large enveloped viruses
New high-performance PES membranes:
Economical solution for upstream virus media filtration
Highest capacities and flow rates
No impact on cell culture performance
Sterile delivery due to gamma irradiatable capsule design:
- Ready to use
Easy implementation into single-use processes
|Model virus for small non-enveloped virus|
|Model virus for large enveloped viruses|
Virosart® Media shows high retention for all tested organisms. The reliable performance of the media virus retentive filter helps to mitigate risk and enhance speed from process to commercial scale.