Process Optimization Strategies For Virus Filtration of Human Plasma Products

Learn how different types of adsorptive pre-filters reduce the binding of highly fouling species, determining the throughput of the final virus filter as well as the overall process economics of the virus filtration step for plasma-derived proteins. In addition, other possible strategies to counteract fouling of the final virus filter are discussed such as dilution of the feed stream.

Key Learning Objectives: 

  1. Fouling mechanisms and their relation to throughput for virus filters from different matrices
  2. Process optimization strategies to increase the robustness of filter fouling
  3. Proof that critical process parameters do not affect viral retention for surface-modified PESU virus filters
  4. Validation strategies and best practices for integrity testing of virus filters and adsorptive pre-filters

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