The Octet® R8e BLI System is the latest innovation in label-free, real-time biomolecular analysis, offering the most advanced detection capabilities in biolayer interferometry (BLI) technology.
Designed to support complex workflows in drug discovery, process development, and GxP environments, the Octet® R8e delivers superior sensitivity, flexible assay design, and longer run times.
Complete with 21 CFR Part 11 compliance solutions, this next-level BLI system facilitates straightforward and confident data-driven decision-making.
Quantify down to 3.9 ng/mL (26 pM) with clear, reliable signal.
Measure small molecules >100 Da
Capture detailed kinetic profiles for molecules as small as 100 Da. Methanesulfonamide (97 Da) binding to carbonic anhydrase.
Run overnight kinetic assays
The newly introduced evaporation control preserves sample integrity for up to 16 hours, making it essential for studies with slow off-rates and extended association periods.
Conserve precious samples
Work with as little as 40 μL per well without sacrificing data quality or throughput.
The Octet® R8e supports 384-well microplate formats, enhancing cost efficiency through smaller sample volumes that reduce reagent and material needs, thereby lowering assay costs. It demonstrates excellent precision across microplate formats.
Capture of fast, initial kinetics
4x faster acquisition for precise detection of initial and fast binding.
Analyze hundreds of samples in a single assay
With the newly added 384-plate capability, you can now measure four times the number of samples per plate.
Easily study equilibrium binding
R8e provides ample time for binding reactions to reach equilibrium without the constraints of sample dispersion, resulting in more reliable kinetic analysis.
Achieve highly consistent results
Replicate Percent Coefficient of Variation (%CV) of just 1.6%.
Assess 100-minute dissociations easily
The new evaporation cover makes assessment of 100-minute dissociations easy.
Go from idea to decision in the same day
Octet® R8e system streamlines the experimental process, allowing scientists to efficiently transition from conceptualizing an idea to making data-driven decisions within the same day. This rapid turnaround is crucial in research environments where time and accuracy are of the essence.
Overview of the Octet® R8e
Fluidic-Free Design
Minimal maintenance, no cleaning between runs, and reusable samples for rapid assay development.
Label-Free Analysis
Preserves protein integrity and saves time and costs by eliminating the need for labeling for detection.
384-Well Plate Compatibility
Supports high-throughput workflows by increasing sample capacity and maximizing data output, while achieving reliable results with as little as 40 µL of analyte conserving precious samples and cutting reagent costs.
Evaporation Control
Boost accuracy and precision in kinetics, affinity, and quantitation assays by maintaining analyte concentrations over time (16 hours) with new evaporation control capabilities.
High-Speed Data for Precise Kinetic Insights
Accurately capture fast kinetics with the enhanced data acquisition feature.
Best-in-Class Sensitivity
Improved signal-to-noise ratio for precise detection of low molecular weight and low-concentration analytes.
Learn how the new Octet® R8e elevates BLI technology to the next level for a label-free biomolecular interaction analysis.
Request a quote or demo
See the Octet® R8e in action and discover how it can transform your research.
The Octet® platform is a comprehensive tool for screening and characterizing molecular interactions, including protein-protein and protein-drug interactions. It supports a wide range of applications across various stages of biologics and drug development, from early selection and validation to manufacturing.
Disposable, single-use fiber optic biosensors with optional reuse by regeneration and re-racking in the sensor tray
Information Provided
Yes/No binding - Kinetic and affinity analysis (kobs, ka, kd, KD) - Specific and selective detection of molecules, even in crude samples - Relative and absolute quantitation of specific proteins in crude matrices or purified samples - Relative potency (EC50) and Inhibition (IC50) analysis?
Sample Types
Proteins, antibodies, peptides, DNA, RNA, liposomes, viruses and VLPs in various media including serum, buffers containing DMSO, periplasmic fractions, bacterial cells, nanoparticles, untreated cell culture supernatants and crude cell lysates
Number of Spectrometers
8
Maximum Simultaneous Reads
8
Data Collection Rate
Variable
Sample Position and Format
One standard 96-well or 384-well black, flat bottom microplate, or 384-well black tilted well plate
The Octet® R8e features advanced evaporation control for the 96-well plate format, allowing for up to 16 hours of uninterrupted operation while maintaining analyte integrity, reducing the need for manual intervention, and improving data accuracy. This means the system delivers consistent, reliable results even during long or over-night experiments.
The Octet® R8e System is a cutting-edge, 8-channel biolayer interferometry (BLI) system designed for real-time, label-free biomolecular analysis. It features a fluidic-free design that minimizes maintenance, simplifies workflows, and ensures consistent data accuracy. The Octet® R8e boasts best-in-class sensitivity, extended walk-away operation, and supports GxP compliance. With its high throughput and robust performance, the system is ideal for complex drug discovery and process development applications.
With compatibility for both 96- and 384-well plates, the Octet® R8e is designed to support high-throughput workflows. The system’s 8 channels enable parallel data acquisition, allowing labs to process multiple samples simultaneously, boosting efficiency and maximizing productivity.
Yes, the Octet® R8e is designed for seamless assay transferability across platforms. Methods developed on older Octet® BLI systems can be easily transferred without compromising data integrity or comparability, ensuring smooth transitions and consistent results across your lab’s operations.
The Octet® R8e requires as little as 40 µL of sample per well, making it highly efficient and cost-effective, especially when working with precious or limited sample quantities. This low sample volume capability helps conserve reagents and minimize costs. Furthermore, the measurement is non-destructive and the sample plate can be recovered for further usage.
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