Sample Prep for Quality Control

Quality control (QC) is a critical step in the pharmaceutical and biopharmaceutical industry. Every pharmaceutical manufacturer must demonstrate that their products are consistently manufactured, safe, potent, and pure. The number of tests that must be run by QC labs continues to rise to meet the ever increasing QC requirements of global regulatory agencies.

Pharma Compliant Weighing

Sartorius’s Cubis® II is designed to follow US FDA data integrity principles that require data to be accurate, legible, contemporaneous, original, and attributable (ALCOA).

The Cubis® II balance, with pharma package, contains all the technical controls to support full compliance with common regulations.

Learn more about Cubis II 

NEW White Paper: Advanced Compliance For Use in Regulated Sectors
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HPLC sample preparation
Clean samples = clean results

HPLC is one of the most common high-precision analytical methods. Its primary objective: deliver reproducible and specific results. A sample needs to be optimally prepared so it can be injected directly onto an HPLC column.

To accomplish this, your sample not only needs to be dissolved in the appropriate solvent. Even more important, it must also be free of particles to rule out interference in the best possible way during detection and to prevent blockage of your column. Sample preparation for HPLC analysis can be a tedious, time-consuming chore, but it doesn’t have to be--

Sartorius solutions save time and increase the reproducibility of your HPLC results.


Impact of the Claristep® Filtration System on Recovery and Adsorption of Various Therapeutic Proteins at Low Sample Volumes 

We tested the novel filter device Claristep® for the preparation of protein samples containing one of four different biotherapeutics. In comparison to the standard protocols...

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Ultrapure Water for HPLC Analysis

The quality of a solvent is often decisive for the reliability of an HPLC analytical run, as the presence of trace contaminants during gradient elution can result in “ghost or phantom peaks.” Deionized or distilled water still contains considerable quantities of organic substances...

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Your HPLC results can only be as good as your sample prep quality

Non-optimized Sample Prep

Chromatogram with pronounced background noise and peak tailing

In HPLC analysis, problems originating from sample preparation can occur.

  • Possible blockage of your HPLC column
  • Lower sensitivity of your HPLC column
  • Peak Tailing
  • More false-positive peaks
  • Higher background noise
  • Leachables

Optimized Sample Prep

Chromatogram with a stable baseline and symmetrical peaks

Using Sartorius products to prepare samples for HPLC prevents the usual problems from occurring and permits higher analytical accuracy to be attained.

  • No blockage of your HPLC column
  • Higher sensitivity of your HPLC column
  • Higher accuracy
  • Fewer false-positive peaks
  • Less background noise
  • No leachables

For high sensitivity analyses, every detail counts.

Let us convince you how you can save time with our solutions and at the same time increase the reproducibility of your results:

Step 1. Preparation of Solvents

arium® mini plus UV and arium® pro ultrapure lab water systems

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Step 2. Preparation of Standards

Cubis® balance with Q-App software

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Step 3. Pipetting

Tacta® and Picus® pipettes with Low Retention tips

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Step 4. Filtration

Claristep® filtration system and Minisart® HPLC syringe filters

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Innovative Discovery: Fast & Simple

Sample Prep Solutions for HPLC & More

Our analytical sample preparation solutions combine our legendary quality and reliability with our design wisdom to provide the very best in high pressure liquid chromatography (HPLC), liquid chromatography–mass spectrometry, ion chromatography (LC-MS, IC), or inductively coupled plasma mass spectrometry (ICP-MS) filtration solutions.

  • Fast, simple, & economical
  • Low retention volumes & maximal recoveries
  • Almost zero leachables or extractables

Resources — HPLC Sample Prep QC

Brochure: Solutions for Pharmaceutical Sample Prep Quality Control

PDF | 2.9 MB

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