The Industry Standard High Throughput Bioreactor, Now Optimized for Process Characterization
Accelerate Bioprocess Development with Improved Scale-Down Performance and Cutting-Edge Analytics
Upstream biopharmaceutical development is complex, costly, and time-consuming. Challenges include:
- Reducing development timelines without expanding resources
- Managing high operational costs due to resource-intensive process characterization
- Efficiently overcoming data integrity and regulatory hurdles
The Ambr® 250 High Throughput Generation 2 tackles these challenges with fully optimized, multi-parallel, automated scale-down bioreactors designed to replicate large-scale systems, reducing time, effort, and cost in process development.
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Building on the proven success of its predecessor, the Ambr® 250 High Throughput Generation 2 introduces continuous gassing, enhanced data integrity, next-generation analytical capabilities, and an optimized user interface. These advancements solidify the system as the ultimate scale-down, multi-parallel platform for biopharmaceutical companies striving to achieve faster process optimization, characterization, and intensification.
With systems installed in major biopharmaceutical companies and CDMOs worldwide, the Ambr® 250 High Throughput has set the industry standard for scale-down bioreactors for early process development and process characterization.
Maximize efficiency with a liquid handler supporting up to 24 single-use 250 mL bioreactor vessels.
Precise gas control improves oxygen transfer rates (kLa) and pCO2 modulation, enhancing scalability.
Streamlined user interactions with improved audit tracking, tamper-proof data files, and master recipe options.
Integrated real-time cameras for monitoring liquid handling and enabling remote troubleshooting.
Available in 12-vessel and 24-vessel configurations, supporting the set-up of high throughput experiments
Maximize Efficiency, Cost-Effectiveness, and Future-Readiness
The Ambr® 250 High Throughput Generation 2 is more than a scale-down model for early process development and process characterization—it is a catalyst for process intensification, cost optimization, and digital transformation. The platform enables scalable, data-driven bioprocessing, accelerating development and maximizing ROI. Its advanced analytic capabilities will seamlessly integrate into next-generation smart labs.
How the Ambr® 250 High Throughput Powers Process Intensification
Process intensification approaches help to reduce costs, increase productivity, and accelerate time-to-market. The Ambr® 250 High Throughput Generation 2 is a core enabler of these strategies by providing:
- High Throughput Parallel Processing – Run multiple experiments simultaneously to quickly optimize conditions.
- Supports Perfusion & Fed-Batch Processes – Integrates into intensified workflows with flexible bioprocessing options.
- Scalable Process Development – Transition smoothly from R&D to production with conditions that mimic large-scale bioreactors
- Improved Control With Continuous Gassing – Reduce variability and enhance process robustness with more precise gas flow
- Automated Sampling & Monitoring – Improve efficiency and remove manual intervention with real-time analytics.
Learn more about how Ambr® 250 High Throughput Generation 2 supports process intensification. Watch our webinar about optimizing perfusion parameters for intensified production of CAR-T cells.
Tour of the Ambr® 250 High Throughput
Explore the New Features of the Ambr® 250 High Throughput Generation 2
Step into the future with the Ambr® 250 High Throughput Generation 2! Browse the latest innovations—from continuous gassing and real-time BioPAT® Viamass monitoring to remote vision system capabilities—designed to optimize process development and scalability.
Ambr® 250 High Throughput Vessels
Single-Use Bioreactor Vessels
The Ambr® 250 High Throughput Generation 2 system offers a variety of single-use bioreactor vessels, each tailored to specific process needs, ensuring flexibility and efficiency in bioprocess development. Each vessel type is designed for compatibility with the Ambr® 250 High Throughput Generation 2 system's automated liquid handling platform, ensuring seamless integration and efficient workflow.
Download the Ambr® 250 High Throughput Consumables Brochure for details on vessel configurations and accessories.
Vessels for Fed-Batch Applications
The Ambr® 250 High Throughput is compatible with a range of bioreactor vessels designed for mammalian and microbial cultures. Each vessel features spareger, impeller(s), integrated feed lines, and advanced sensors for precise control and monitoring.
- Mammalian Culture Vessels – Available in baffled designs with dual pitch-blade impellers for efficient mixing, and unbaffled single impeller design for gentle mixing.
- Microbial Culture Vessels – Equipped with dual Rushton-type impellers and optional external condensing bottles for enhanced performance.
Optimize your fed-batch processes with vessels tailored to your specific bioprocessing needs.
Perfusion Vessels for Continuous Processing
Ambr® 250 High Throughput perfusion vessels are designed for seamless integration with alternating tangential flow (ATF) and tangential flow filtration (TFF) modes, ensuring efficient continuous cell culture. Each vessel is equipped with pressure sensors, pump chambers, and calibrated tubing for precise process control.
- ATF and TFF Compatibility – Choose vessels tailored to your preferred perfusion strategy.
- Customizable Filtration – Select from various filter pore sizes or opt for filterless designs.
- Enhanced Gas Exchange – Optimze oxygen transfer with the integrated microsparger.
Achieve high-density cell culture with vessels built for process intensification and scalability.
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Ambr® 250 High Throughput Generation 2 Bioreactor System - Product Information and Specifications
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FAQs for Single-Use Multi-Parallel Bioreactors
Multi-parallel bioreactors allow researchers to run multiple small-scale experiments simultaneously, optimizing process conditions faster and reducing development time.
High throughput process development involves running multiple bioprocess experiments in parallel using automated systems, enabling faster screening and optimization of culture conditions.
Continuous gassing ensures a stable gas flow, mimicking large-scale bioreactors more effectively and providing precise control over oxygen and CO₂ levels.
Fed-batch cultures involve periodic nutrient additions, while perfusion cultures continuously refresh media, enabling higher cell densities and prolonged culture viability.
Process intensification enhances productivity, reduces costs, and accelerates time-to-market by increasing cell densities and optimizing resource utilization.
