Future-Ready Organizations Prioritize Data Analytics and Collaboration
The importance of collaboration was a key topic at the 2022 Sartorius Data Analytics User Meeting. This blog post reviews how some of our key data analytics partnerships drive innovation in bioprocessing.
This article is posted on our Science Snippets Blog
Being a future-ready organization requires a flexible operating model, which involves a combination of multidisciplinary teams and on-demand technologies that work across a broad ecosystem of partners.
Sartorius Data Analytics is continually expanding its partner network in the areas of process analytical technologies (PATs), quality by design (QbD), and design space and multivariate calibration using spectroscopic instruments in order to:
- provide a greater variety of solutions
- enhance customer experience
- provide greater convenience
- generate additional value
At the 2022 Sartorius Data Analytics User Meeting, we were proud to showcase several of our partners, including Waters Corporation, 908 Devices, Emerson, and Endress+Hauser, over the two-day event in Jersey City, NJ.
Here are some of the highlights:
In-Process Media Monitoring Using the BioAccord™ LC-MS and MVDA from Multi-Parallel Ambr® 15 Microbioreactor System
Mark Wrona, Consulting Scientist, Waters Corporation
Waters Corporation is a leading provider of lab equipment, supplies, and software for scientists worldwide. Waters and Sartorius announced their partnership in the space of analytical mass spectrometry in 2021, with the sole intention of helping joint customers accelerate clone selection and process development.
At this year's user meeting, Waters presented how the Sartorius Ambr® 15 and Waters BioAccord™ LC-MS system can be used in combination to accelerate bioprocess development timelines.
Combing Sartorius' Ambr® 15 with Waters’ BioAccord™ LC-MS system enabled scientists to collect up to seven critical quality attributes (CQAs) and 200 cell media components from 48 samples every two days. Optimized and integrated workflows, with seamless data transfer and reporting, allowed results to be imported and exported into both Ambr® 15 software and Waters’ waters_connect™ platform.
Cell culture media analytics, supported by multivariate tools, were then used to assess the impact of raw materials and cell health based on consumption rates and correlations to other CQAs and critical process parameters (CPPs).
Johan Hultman, Manager of OEM Data Analytics with the Ambr® 15 Cell Culture Bioreactor System
Read more about Ambr® 15 and Ambr® 250 Compatible Analyzer Technologies here
Empowering Process Optimization: Rapid At-line Amino Acid Monitoring Coupled with Integrated Multivariate Analytics
Ji Young Anderson, Senior Scientist, 908 Devices
908 Devices is best known for its analytical mass spectrometry with simple handheld and desktop devices. 908 Devices’ REBEL at-line amino acid & vitamin analyzer stood front and center during their presentation at this year's user meeting.
“REBEL data can feed seamlessly into the Umetrics® Suite products SIMCA® and MODDE® for rapid data visualization and multivariate trend tracking”.
- Ji Young Anderson, Senior Scientist, 908 Devices
By combining powerful analyzers like the REBEL system with data analytics, bioprocess developers can quickly perform media quality control, track trends, understand cell consumption rates, and remedy key components in media depletion to enhance QbD initiatives.
Emerson and Sartorius Collaborate to Deliver Spectral PAT Capabilities
Michalle Adkins, Director Life Sciences Consulting, Emerson
Emerson Global is an industry titan in the automation and process control world. Within bioprocessing, they are most well known for their DeltaV™ system.
The reason why Sartorius and Emerson chose to collaborate was to improve the integration of PAT with supervisory control systems. As a result, SIMCA®-Q has been encapsulated within the DetlaV™‘s embedded Spectral PAT function block and is used to build MVDA models for spectral analyzer measurements. These models can be easily transferred and accessed by DeltaV™ for seamless integration into the automation protocol.
Interested in embedding SIMCA®-Q into your OEM solutions? Contact our team
Cross-scale Raman Spectroscopy in Bioprocess
Nick MacLean, Applications Scientist, Endress+Hauser
Endress+Hauser is a leading supplier of measuring devices, services, and solutions for industrial process engineering. To enrich their Raman upstream bioproduction portfolio, Endress+Hauser has partnered with Sartorius on multiple levels, including as an OEM partner using SIMCA®-Q, with the Ambr® team, as well as BioPAT® MFCS SCADA.
In his presentation, MacLean highlighted a Lonza success story, where SIMCA®-Q was used to create models for glucose, lactate, TCC, VCC, glutamate, ammonium, and product concentration to support clinical and commercial manufacturing operations.
“PAT and QbD as well as enabled continuous monitoring and control of nutrient feeds provided a more robust and consistent process”.
- Nick MacLean, Applications Scientist, Endress+Hauser
Interesting in upgrading your supervisory control system with MVDA? Click here
The Power of Partnerships
There’s no better approach to solving problems than the well-known saying, “two heads are better than one.”
At Sartorius, we are firm believers that strategic partnerships fuel business growth and build more value for our customers. Therefore, we are committed to continual growth and progress in the space of OEM and embedded solutions.
“We are in a golden age of information. Each one of us having different experiences and expertise. By working together through collaborations and partnerships in today’s fast pace environment, we can accelerate innovation in the field, combining the best aspects of our solutions that customers need.”
– Andrew Hines , OEM & Embedded Solutions Account Manager, Sartorius Data Analytics
Want to partner with us? Click here to read more.
