Cell Therapy MSC Mesenchymal Stem Cell illustration

Innovative Tools for Streamlined MSC R&D Workflows

Maximize MSC Research with Deeper Insights, Automation, and Enhanced Characterization

Mesenchymal stem cells (MSCs) are adult stem cells isolated from various sources such as bone marrow, adipose tissue and umbilical cord. They are multipotent cells with the capacity to differentiate into cell types such as osteocytes (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and fat cells of adipose tissue (adipocytes).

MSCs secrete a host of chemical messengers, including chemokines, cytokines, growth factors, metabolic products and small molecules such as microRNAs (miRNAs), which act on neighboring cells to produce biological effects.

The potential of MSCs to differentiate into various cell types and their immunomodulatory functions make them attractive candidates for regenerative therapies and chronic inflammatory disease treatment.

Effective advanced cytotherapies require reliable equipment and bioprocesses to move from research to clinical phases and eventually gain regulatory approval. Challenges can include: 

  • Controlling variability to ensure reproducibility of experiments
  • Automating assays to understand and characterize MSCs and their therapeutic effects
  • Running assays at throughput to accelerate the development of insights
  • Characterizing the phenotype and function of MSCs and affected tissues to measure therapeutic effect of MSCs
  • Gaining insight into MSC therapeutic potential through extensive characterization to establish critical quality attributes (CQAs)

MSC Therapy Research & Development Benefits

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Comprehensive Characterization

Gain biological insights into MSC phenotypes and therapeutic effects through in-depth cell characterization

Control and Reproducibility

Ensure study reproducibility by effectively managing MSC donor, culture and reagent variability

Biosafety

Ensure patient safety with rapid detection of mycoplasma as well as bacteria and fungi in just three hours

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Featured MSC Therapy Research & Development Products

Cell selection and retrieval instrument with dual monitors

CellCelector Automated Cell Selection and Retrieval Platform

Fully automated solution for the identification, targeted isolation and passaging of the desired stem cell colonies or clones.

Automated counting and picking of individual stem cell colonies to access myeloid vs. erythroid colonies, differentiation state, gene expression profiles or gene mutations.

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Incucyte® CX3 Live-Cell Analysis System

Transform your 3D cell model workflows with reliable image resolution using new confocal imaging! Choose both fluorescence-based and label-free assays to continuously monitor morphology, growth, and phenotypic changes in spheroids, organoids, stem-cell-derived models, and patient-derived 3D cultures, and gain physiologically relevant data without disrupting the culture. Additionally, the system is optimized for high-throughput workflows, making it ideal for large-scale applications.

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iQue® 5 High-Throughput Screening (HTS) Cytometry Platform

The iQue® 5 High-Throughput Screening Cytometer is a high-throughput suspension cell and bead analysis platform for rapidly profiling MSC phenotype and function as well as immunomodulation and cytokine profiling in cell therapy R&D workflows. Ideal for screens where cells are precious or limited in number, iQue® 5 is the fastest way to generate high-content data from small samples and the iQue® 21 CFR Part 11 Software Module ensures compliance for regulated laboratories at every stage.

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 Top down view of Sartorius Microsart ATMP Mycoplasma qPCR Mycoplasma Detection Kit. box and contents

Microsart® ATMP Mycoplasma — Rapid Real-time PCR Mycoplasma Detection Kit

Microsart® Mycoplasma qPCR detection kits: a rapid and guideline-compliant solution for mycoplasma detection. These kits are fast, highly specific, sensitive, and compliant with international guidelines.

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An open box of Sartorius Microsart ATMP Sterile Release and its contents

Microsart® ATMP Sterile Release Detection Kit

Rapid Bacteria and Fungi Detection in Only 3 Hours with Microsart® ATMP Sterile Release Kit. The qPCR-based kit detects a broad range of gram-positive and gram-negative bacterial and fungal contaminants.

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Mesenchymal Stem Cell Media

MSC NutriStem® XF supports the isolation and expansion of hMSCs, providing high-quality cultures for research and cell-based therapies.
•    Xeno-free, serum-free  
•    Superior proliferation rate  
•    Maintain cell characteristics and differentiation potential
•    Custom scale-up and optimization services
•    Smooth transition from RnD to manufacturing
•    Scientific and regulatory support
•    cGMP manufactured
•    DMF available


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Featured Resources

MSC Therapy Research & Development Resources

Application Note

Elevate MSC Quality Standards: Incucyte Application Note

Leverage live‑cell analysis with HTS cytometry to dynamically monitor MSC growth, morphology, senescence, and optimize culture quality.

Application Guide

Rapid Assessment of MSC Differentiation: Application Note

Live‑cell imaging plus HTS cytometry enables real‑time, multiplex analysis of MSC differentiation — faster, dynamic, and preserves cells.

Mesenchymal stem cell SEM stock image - pink cell on brown background
eBook

The Promise of Regeneration

MSCs and Exosomes in Modern Medicine.

Incucyte® 21 CFR Part 11 Software Module

Secure and configurable software module to track all system events and user actions.

Fully automated image-based single cell and colony picking for stem cells
Application Guide

Fully Automated Image-Based Single Cell and Colony Picking

Stem cells play an important role in the field of regenerative medicine for a wide range of biomedical and pharmaceutical research applications

First Final Release Test of ATMPs Prior to Treatment Validation of a qPCR-Based Rapid Sterility Test
Poster

Rapid Sterility Testing for Cell Therapy Quality Control Poster

In this poster, a validation study was designed to evaluate bacterial and fungal detection capability.

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