Celsius® S3 Benchtop Freezing Platform
Offering Reliability at Scale
The Celsius® S3 benchtop freezer is a small-volume controlled-rate freeze/thaw system with single-use containers that creates freeze/thaw kinetics scalable to production scale operations. This device is a process development tool to execute scale-up, scale-down and stability studies using a minimal amount of product.
Provide a reliable simulation of commercial-scale processes for seamless scalability by reproducing freezing and thawing process times
Flexibility to process from 1 to 10 product samples, reproducible performances, and batch-to-batch consistency
Automated operation and data collection combined with accurate temperature monitoring at well-defined last-point-to-freeze location
Enable storage/transportation studies, formulation development, and stability studies for comprehensive freeze/thaw characterization activities
Controlled and Reproducible Freeze/Thaw Performance
The Celsius® S3 Benchtop Freezing Platform is comprised of the Celsius® S3 benchtop freezer and lab-scale Celsius® Pak 30 mL and 100 mL bags. This complete solution provides documented and reproducible processes facilitating validation of freeze/thaw operations with full scalability to commercial-scale Celsius® platforms (CFT, FFT, and FFTp).
Celsius® S3 Benchtop Freezer
The Celsius® S3 Benchtop Freezer provides the ability to replicate commercial-scale plate (vertical/horizontal), blast, and conventional freeze/thaw methods for:
Process development studies to understand decoupling steps during downstream processing, such as frozen storage of drug substances.
Scale-down freezing studies to assess extended cooling and thawing profile of drug substance using minimal volumes
Stability studies to simulate proposed packaging for production-scale freezing, storage, shipping, and thawing
Lab-Scale Celsius® Pak 30 mL and 100 mL Bags
Lab-scale Celsius® Paks, available as 30 mL and 100 mL single-use bags, are made with the same product contact layer as commercial-scale Celsius® bags.
Celsius® Paks offer the following benefits:
- E&L profile consistency across all Celsius® containers
- In-line temperature monitoring capabilities
- Robust performance down to -80°C
- Compatible with the S3 Benchtop Freezer and conventional freeze/thaw method