Freeze/Thaw Solutions for Seamless Scalability to Commercial Production
Safe, Reliable and Adaptive Frozen Transfer Solutions
Building on more than 15 years’ experience in designing freeze and thaw solutions, Sartorius offers lab-scale and production-scale solutions for every process step when frozen storage and frozen shipment are required. This allows biopharmaceutical manufacturers to effectively decouple downstream process steps and securely transport drug substances to drug product sites. With options that accommodate blast, horizontal and vertical plate freezers, the Celsius® platform offers an end-to-end, integrated approach that enables monitoring and controls to assure product quality and integrity at scale.
Safely and confidently manage the entire cold chain, from filling and freezing to shipping, thawing and dispensing.
Flexible implementation according to product and process needs
Unparalleled supply reliability based on control of manufacturing processes and global production operations.
A system built on purpose-driven design to reduce manual handling of drug substance and minimize/prevent risk of cryoconcentration.
Robust by Design: Addressing New Challenges in Bulk Drug Substance Management
Up to 25% of vaccines are believed to be lost due to cold chain failures. Learn how Celsius® FFT and FFTp containers prevent losses.
Find the Right Celsius® Solution
Sartorius offers fully integrated, end-to-end freezing solutions, as well as the flexibility to introduce quality freezing containers into existing freeze/thaw operations and infrastructure. Explore freezing storage and shipping solutions based on infrastructure or product needs.
Attribute | |||
|---|---|---|---|
Platform | Complete platform | Container plus shippers | Container plus shippers |
Freezer type | Vertical plate freezer | Conventional and blast freezer | Horizontal plate freezer |
Controlled freeze/thaw | Yes | Possible in blast freezer | Yes |
Load capacity | 100L per thermal cycle | Depending on freezer type | 200L per thermal cycle |
Container range | 1L – 16.6L | 2L – 12L | 6L – 12L |
| Explore Celsius® CFT |
End-to-End Platform Celsius® CFT
Celsius® CFT (Controlled Freeze and Thaw) is a fully integrated, end-to-end freeze/thaw solution that reduces risk by minimizing the handling of drug substance, while a controlled-rate plate freezing and thawing system minimizes cryoconcentration.
Proven performance to -80°C
Complete solution from filling through draining
A robust and reliable platform for cGMP manufacturing
Celsius® FFT: Stackable Freeze Containers for Simplified Operations
Celsius® FFT (Flexible Freeze and Thaw) is a sterile, pre-assembled, ready-to-use freeze container with a unique bag-in-shell system that works seamlessly in any conventional or blast freezer.
Proven performance to -80°C
Leveraging existing freezer infrastructure
Bulk processing with versatile multi-modal shipping solutions
Celsius® FFTp: SU Containers Designed for Horizonal Plate Freezers
Celsius® FFTp (Flexible Freeze and Thaw for Plate Freezer) offers the unique bag-in-shell system, but with a flatter, more compact design to fit perfectly against the surface of a horizontal plate freezer.
Proven performance to -80°C
Fast and reproducible thermal cycling
Purpose-designed box shippers
AliquoT® Automated Filling
AliquoT® automates drug substance distribution to Celsius® containers with high accuracy and cost savings without the risk of tolerance breach.
Building on more than 15 years of expertise in freeze/thaw solutions, Sartorius offers frozen storage and shipping solutions to meet the challenges of the biopharmaceutical cold chain. With global operations and an extensive network of engineers and industry experts, Sartorius provides the technology, expertise and support manufacturers need to succeed.
