A Full-Service Cell Line Development

Rely on Our CLD Experts to Generate Your High-Performing Cell Lines

As the worldwide demand for protein therapeutics has grown, so has the need for suitable production cell lines. Sartorius can help meet this need with our industry-leading cell line development services aimed at the commercial manufacturing of biopharmaceuticals. Based on our unique cell line development technology, we reliably generate high-performing, stable CHO production cell lines on accelerated timelines.

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Superior Performance: Up to 10g/L

Proprietary and superior CHO cell line development technology that ensures a robust and scalable bioprocess with high product yield (up to 10g/L for monoclonal antibodies) and quality.

Impressive Speed: RCB in 9 weeks

From DNA to Research Cell Bank (RCB) in only 9 weeks. No need for time-consuming media and process optimization or scalability studies. Regulatory ready documentation package.

Outstanding Reliability: 240+ projects

More than 240 cell line development projects. Benefit from our know-how and experience and get your cell line right the first time.

Low Financial Risk: Pay as you go

No hidden fees, no cancelation fees, no milestone payments.


Building the Next Generation of Cell-Line-Development Platforms

Learn how we have significantly reduced CLD timelines by using advanced platform technologies to deliver high-producer clones.

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Explore Sartorius' Next-Generation Cell Line Development Service

Continuously improving to better meet your needs, we have launched our new CLD Service as part of the 4Cell® CHO platform. CLD Service is powered by the new clone selection technology, CellCelector™ system, to facilitate high-throughput isolation and cloning of individual cells, allowing us to reduce the transition of DNA to RCB significantly down to 9 weeks.

Combined with an efficient expression vector and proprietary CHO host cell line, selected high-producer clones can achieve titers up to 10 g/L with the high-performing 4Cell® SmartCHO media. Additional services for process intensification and genetic engineering have also been added to our service offering.

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Track Record

4Cell® CHO Platform Cell Line Development

  • Established track record with more than 240 CLD projects​
  • Our CLD platform works with non-mAbs and “difficult to express” molecules

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Single Cell Cloning​

Replacing FACS by Sartorius CellCelector™ for Single Cell Cloning

  • Speed: removal of pool phase leads to 5 weeks time saving​
  • Efficiency: improved cell outgrowth leads to minimum loss of high producers due to cell death after single cell cloning​
  • Regulatory compliance: statistically evaluated procedure granting monoclonality proof for regulatory agencies

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Clone Selection

Optimized Clone Selection by Fluorescence-based Productivity Assay​ and Small-Scale Fed-Batch

  • Early elimination of low producers​
  • Improved detection of high producers​
  • Proven scalability from clone selection to large-scale biorecators

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Additional Services

Genetic Engineering​

  • FUT8 knock-out option for increased ADCC: service implemented and ready-to-use​
  • Customized knock-outs possible, e.g. for modified glycosylation profile​

Process Intensification​

  • High-inoculation fed-batch: Achieve higher titer (to standard fed-batch) in comparable time or comparable titer in shorter time​
  • Selection of high performing perfusion-ready clones in our Ambr15® perfusion mimic

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Related Webinars


Next-Gen CHO Cell Line Development Services

Learn how an expert partner can help accelerate cell line development, reduce risk, and improve outcomes with advanced tools and technology.

Watch Webinar

Novel Single-Cell Cloning Technology in Cell Line Development Webinar

Cell line development (CLD) is the process of generating a cell line which stably expresses a biopharma product at high amounts and in optimal product...

Watch Webinar

Related Resources


4Cell® CHO Platform Service Package: The Fast Track to IND

PDF | 1.8 MB

Cell Line Development Service

PDF | 740.0 KB

4Cell® CHO Media and Feed Portfolio

PDF | 1.6 MB

Cell Bank Manufacturing & Characterization

PDF | 1.5 MB

New Biological Entity - Product Characterization Services

PDF | 814.3 KB

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