High Throughput Automated Micro Bioreactor for High Density Fed Batch Strain Selection
ambr® 15 fermentation is a high throughput automated bioreactor system for 24 parallel microbial fermentations in a cost-effective 8 –12 mL micro bioreactor format.
It has a wide range of applications in:
- Strain selection
- Vector screening
- Media and feed development
- Early process optimization
- QbD and DoE studies
- ambr® 15 fermentation is based on the gold standard ambr® 15 technology
- It provides a consistent microscale model for early stage microbial screening experiments with fed-batch culture capability
- It offers automated parallel processing and control of 24 bioreactor experiments by one operator
- Designed to support high density culture through effective mixing, gassing and fast response to changes in culture parameters
- Now available with integrated online biomass measurement for real-time continuous growth monitoring of microbial cultures
System Features
- Online monitoring and closed-loop control of pH, DO and temperature for each bioreactor
- Culture station control of impeller speed
- Independent control of gas flow rates (N2, air and O2) for each bioreactor
- Cascade DO control system for gas flow, stirrer speed and gas mixture
- Automated liquid handling for bioreactor set-up, feeds, base addition and sampling
- Software controls and monitors all experiments and records data and events
ambr® 15 Transforms Early Process Development
- Provides predictive screening results early in development
- Enhances scalability over shaken cultures
- Comparability to benchtop bioreactors
- Enables data rich culture profiles
- Increases lab productivity
ambr® 15 fermentation Tour
ambr® 15 fermentation Vessel Tour
ambr® 15 fermentation + ambr® analysis module
The ambr® analysis module enables automated pH measurement, both for initial bioreactor
vessel pH sensor calibration and subsequent in-process re-calibration - improving pH control
and culture performance.