Octet® SPR Streptavidin in Dextran Hydrogel (SADH) Sensor Chip

The interaction between streptavidin and biotin results in a high affinity biomolecular interaction with negligible dissociation of the ligand from the sensor chip surface, making it an ideal choice for high-capacity, reproducible SPR experimentation. The Octet® SPR SADH sensor chip consists of streptavidin pre-immobilized on a 3D carboxymethylated dextran hydrogel, which allows binding to a variety of chemically or enzymatically biotinylated target ligands. Due to the highly efficient binding between the immobilized streptavidin and the biotin tagged ligand, only low nanomolar concentrations of the ligand are usually required.  

Top Features of the Octet® SPR Streptavidin in Dextran Hydrogel (SADH) Sensor Chip: 

  • Medium to high binding capacity
  • Surface has lower electrostatic charge compared to amine sensors
  • Binding resistant to wide range of conditions including heat, pH and proteolysis

Popular Applications for the Octet® SPR Streptavidin in Dextran Hydrogel (SADH) Sensor Chip:

  • Intermediate and large molecules
  • Kinetics
  • Affinity
  • LMW binding

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Octet® SPR sensor chips have been specifically designed to allow generation of robust and reproducible results for every application – from large molecules, molecular complexes, viruses or whole cells to small molecules or antibody fragments.

The Octet® SPR SADH sensor chip’s controlled ligand orientation facilitates optimal analyte capture with low interference of the target ligand and is validated for a large range of applications.


  • Application
    • Kinetics
    • Affinity
    • Low molecular weight binding


  • Sensors

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