Skip to content Skip to navigation menu

MEP HyperCel - 5 L Mixed-Mode Chromatography Resin

MEP HyperCel provides a unique separation mechanism and selectivity for protein separations, with ligand-based immunoglobulin selectivity optimal for monoclonal antibody capture and intermediate purification. The MEP ligand facilitates the binding of immunoglobulins as well as other target proteins at neutral pH under moderate salt concentrations.

Item no.:  12035-040


MEP HyperCel is a flexible mixed-mode chromatography resin designed for capture and purification of antibodies and various recombinant proteins from laboratory to manufacturing scale.

MEP HyperCel resin offers a no salt/low salt alternative to conventional HIC and can simplify processes and improve economics by removing the need for salt addition and following UF/DF steps. The MEP ligand is immunoglobulin-selective. Thus, MEP Hypercel can be effectively used for IgG capture and for enhanced DNA, HCP and aggregate removal. Elution is under mild conditions.


Features and Benefits

- Unique separation mechanism and differentiated selectivity
- Direct protein capture from a variety of feedstocks
- No salt addition required for binding means a simpler process, lower costs and reduced waste
- Stable toward harsh cleaning with NaOH


- A no-salt/low-salt alternative to Hydrophobic Interaction Chromatography (HIC)
- Monoclonal and polyclonal IgG capture and intermediate purification (aggregate, DNA and HCP removal)
- Direct capture of recombinant proteins or enzymes from feedstock without need for pH or conductivity adjustments

Available formats for MEP HyperCel

Pack SizeOrder Code
25 mL12035-010
100 mL12035-028
1 L12035-036
5 L12035-040
10 L12035-044


 As pre-packed columns:

Pack SizeOrder Code
PRC Column 5x50 MEP HyperCel, 1 mLPRC05X050MEPHCEL
PRC Column 8x100 MEP HyperCel, 5 mLPRC08X100MEPHCEL
RoboColumn MEP HyperCel 200µLSR2MEP
RoboColumn MEP HyperCel 600µLSR6MEP



MEP HyperCel Mixed-Mode Chromatography Resin
en 724.2 kB


  • Application
    Preparative protein purification

Compliance Information

  • Quality Standards
    CoA, RSF


  • Bead Size
    80 - 100 µm

General Specifications

  • Flow Rate
  • Resin Format
    Bulk resin

Materials of Construction

  • Base Matrix
    Rigid cellulose beads

Operating Conditions

  • Operating Pressure
    < 3 barg (44psi)
  • pH Stability
    2 to 14 (short term); 2 to 12 (long term)

Physicochemical Information

  • Ligand
  • Reference Protein
  • Typical Dynamic Binding Capacity 10% per mL
    ≥ 20 mg/mL hIgG at 6' residence time

Product Information

  • Pack Size
  • Pack Volume
    5 L
  • Primary Product Type
  • Resin Delivery Condition
    1M NaCl with 20% EtOH
  • Resin Type
    Mixed-mode anion exchanger
  • What you receive
    1 bottle resin, instructions

Storage Conditions

  • Storage Conditions
    20% EtOH/1M NaCl