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Ksep® 400 System

Advanced, scalable, single-use automated centrifugation systems

Sartorius Ksep® systems provide robust, single-use bioprocessing solutions in the areas of recombinant therapeutics, cell therapy, vaccine manufacturing, and blood processing.

As per your process requirements, our fully-automated systems are optimized to recover supernatant or solids (cells | particles) in a continuous manner.

Ksep® systems solve the problems of traditional centrifugation and filtration based technologies by handling very high cell densities while providing high recoveries and product quality.

Item no.:  KSEP400

   

Patented Ksep® systems technology is the only current technology that provides significant advantages for users that want to either harvest cells as product or discard cells as by-product during manufacturing.

Benefits

Smart Bioprocessing

  • Integrates and | or reduces processing steps and time
  • Improves recoveries of both solids and liquids
  • Provides option to selectively remove small particulate impurities, e.g. plastic generated, cell debris
  • Built-in scalability (4 – 6 fold) for development and manufacturing using the same system
  • Automated with option to run in complete manual mode
  • No hardware change for different applications
  • Handles low to high cell density cultures (>150 million cells/mL) equally well

Advanced Cell Handling

  • Imparts low shear on cells and keeps the cells intact
  • Maintains a healthy environment to sustain cell viability
  • Complete supernatant product recovery from slurry without dilution
  • Reduces intracellular protein contamination for harvest applications by keeping the cells intact

Ensures cGMP Manufacturing

  • Closed system with single-use class VI product contact surfaces
  • Simple, robust, and scalable
  • One software for all systems
  • Clog-free and continuous operation

Applications

  • Harvest | Clarification
  • Cell Therapy
  • Vaccine Manufacturing
  • Blood Processing
  • Learn more at www.sartorius.com/ksep-systems

Datasheet

kSep® Systems - Advanced, Scalable, Single-Use Automated Centrifugation Systems
en 531.5 kB

Connections (Data)

  • Data Transfer
    • USB
    • J45-Ethernet
    • LAN

General Specifications

  • Cell Capacity per Cycle
    (CHO) Up to 80 Billion
  • Flow Rate
    114 L/hr
  • Maximum Gravitational Force
    1,000 g

Power Requirements

  • Power Requirements
    208 – 240 V1 Ph; 20A

Volumes

  • Volume
    400 mL (4 × 100 mL)
  • Working Volume
    0.1 – 500 L

eShop Dynamic Attributes

  • Application
    • Cell Culture (Vaccine)
    • Cell Therapy
    • Cell Culture (recombinant proteins, mAbs)
  • Connections
    ⅜″ × ¼″ C-Flex
  • Connector Material
    C-Flex 374 (TPE)
Ksep® 400 Concentration-Wash-Harvest Reduced Volume Consumable Kit (Cell Harvest)

KSEP400-SETCWHRV consumable kit contains both chamber set and reduced volume valve disposable set.

Ksep® 400.50 Concentration-Wash-Harvest Reduced Volume Consumable Kit

KSEP400.50 Concentration-Wash-Harvest consumable kit with chamber set of two 25 mL chambers and reduced volume tube set.

Ksep® 400 Concentration-Wash-Harvest Consumable Kit (Cell Harvest)

KSEP400-SET-CWH consumable kit contains both the chamber set and the valve disposable set.

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