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Sartoflow® Advanced

Full Flexibility Meets Outstanding TFF Performance

Flexible solution

01. - 2.1 m² membrane sizes | 10 L stainless steel vessel or 5, 10, 20 L single-use bags for recirculation

High product yields

4-piston membrane pump for low shear

Highly automated

Two pumps for feed and buffer addition, as well as full TMP control



* 72 Hours Turnaround Time

Sartoflow® Advanced is suitable for flexible use in laboratory environments, for process development and clinical trials as well as for small-scale production batches. Several standardized options are available that can be upgraded with additional options if requirements change during process development or production.

This TFF system is equipped with the established DCU-4 control unit that readily communicates with BioPAT® MFCS software.

The System can be configured to accept either Sartocon® Slice or full-sized Sartocon® cassettes, providing an exceptionally wide range of membrane surface areas. Since all Sartocon® TFF cassettes have the same hydrodynamic flow path length, the Sartoflow® Advanced can be linearly scaled up from 0.1 to 2.1 m² of membrane area. Its unique compact design has an ultra-low loop volume of ~200 mL, making it possible to concentrate even small process batches.



  • Application
    Purification of mAbs, ADC, vaccines, viral vectors, and recombinant proteins

Compliance Information

  • GMP Compliance

Connections (Physical)

  • Connector
    Tri-clamp (1/2")


  • Dimensions WxDxH
    1,100 × 800 × 680 mm
  • Membrane Area
    0.1 - 0.5 m² (optionally 0.7 - 2.1 m²)
  • Tube Size (ID – OD)


  • Display

General Specifications

  • Cassette Format
    • Sartocon Cassettes
    • Slice Cassettes
    • Standard Cassettes
  • Pump Output
    700 L/h @ 4 bar (60 psi)
  • Surface Roughness of Wetted Parts
    Ra <= 0.6 µm

Materials of Construction

  • Recirculation Vessel
    Stainless steel 316 L

Operating Conditions

  • Maximum Operating Pressure
    4 bar (58 psi)
  • Minimum Operating Volume
    ~200 mL

Power Requirements

  • Power Requirements
    230 VAC | 50 Hz 2.5 Amp; 120 VAC | 60 Hz 4 Amp

Product Information

  • Brand
    Sartoflow® Advanced


  • Recirculation Vessel Volume
    10 L (MU)
  • Volume
    Bag: 5, 10, 20 L (SU)


  • Total Weight
    ~ 120 kg