Sartoclear® Depth Filters

Sartoclear® Depth Filters

Always the Best Solution for Your Harvest

Sartoclear® Depth Filters are cellulose-based filters developed for demanding clarification applications in the pharmaceutical and biopharmaceutical industry. The wide range of grades offers a solution for a variety of applications such as post centrifuge clarification and post perfusion filtration or direct bioreactor harvest.

Sartoclear® Depth Filter application areas

  • Mammalian cell culture harvests
  • Microbial lysates
  • Removal of precipitates from sera and plasma
  • Particle and colloid removal from process intermediates

Product Overview

Sartoclear® Caps

Sartoclear® Caps are easy-to-use screening devices that help you to find the best grade for your application.

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Sartoclear® Depth Filter Cassettes

Sartoclear® Depth Filter Midscale Cassettes are developed for scale-up filtrations with volumes between five to 10 liters.

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Sartoclear® Depth Filter Cassettes

Three different sizes of Sartoclear® Depth Filter Cassettes allow for a seamless adaptation to different process fluid volumes.

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Sartoclear® Depth Filter Modules

Sartoclear® Depth Filter modules are stackable, lenticular shaped depth filters for use in stainless steel housings.

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Find The Optimal Grade for Your Application

Sartoclear® DL-Series are high capacity depth filters made of two distinct filtration layers. The primary coarser layer is followed by a second finer layer which enables the removal of a broader spectrum of particles in a single step.

The Sartoclear® DL-Series are pre-selected and optimized to serve the most common biopharmaceutical applications.

DescriptionApplication examples




Very coarse primary grade on top of a coarse secondary filter for filtrations with high solid concentrations

Primary clarification of mammalian cell cultures, insect cell cultures, microbial fermentations, vaccines




Pure cellulose pre-filter combined with a coarse secondary filter

Primary clarification of mammalian cell cultures, insect cell cultures, microbial fermentations, vaccines




Coarse primary grade with a secondary fine filtration grade for lower to moderate solid concentrations

Post-perfusion bioreactors, vaccines




Fine filtration grade combined with a standard bioburden reduction grade for the removal of particles

Post centrifuge mammalian cell cultures, post primary depth filtration, process precipitates




Fine filtration grade followed by very tight secondary filter for the removal of high concentrations of small particles

Post centrifuge microbial (e.g. E. coli ) lysates, post primary depth filtration step, process precipitates

System Overview of Sartoclear® Depth Filters

Maximize Product Recovery

  • Manifold set comes with pre-installed tubing on vents and drains
  • Tubing with quick connectors at the end can be hooked up with pressurized air or bags
  • Retained medium is recovered through controlled air pressure

Practical Design for Easy Cassette Exchange

Holding grooves allow the user to take each cassette out step-by-step.

Rounded bottoms enable the user to take out used cassettes in an ergonomic way.

Handles enable comfortable carrying with both arms.

Sartoclear® Depth Filters are a full linear scalable solution for cell broth filtration with cell densities <15 × 10 Mio/mL, from process development to commercial manufacturing.

Sartoclear® Depth Filters are available in a variety of formats to serve you from the first steps, throughout clinical phases, and up to large-scale manufacturing while always keeping the same filter material.

  • Sartoclear® Depth Filter caps are easy-to-use screening devices that help you to find the best grade for your application. All packages contain three units of the same grade and come with plug-in Luer adapters for the easiest possible exchange of filters.
  • Sartoclear® Depth Filter midscale cassettes are developed for scale-up filtrations with volumes between 5 to 10 liters (depending on the cell density). They are designed in gradient shape for mechanical reinforcement to meet the application conditions.
  • Sartoclear® Depth Filter cassettes are single-use filtration devices specially designed for biopharmaceutical clarification applications. The modular devices provide linear scalability from small- to large-scale processes. Three different sizes of filter holders allow for seamless adaptation to different process fluid volumes.


Learn more about Sartoclear® Depth Filters


Datasheet: Sartoclear® Depth Filter - Cell Clarification and Contaminant Removal Technologies

PDF | 674.0 KB

Positioning Sheet: Cell Clarification Technologies Matrix

PDF | 585.4 KB

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