Sartorius iPSC Optimization and Characterization Solution

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Sartorius iPSC Optimization and Characterization Solution

Scaled-up, semi-automated, high-throughput expansion and characterization solution to develop process insight through CPP and CQA correlation for a robust iPSC manufacturing protocol

  • Process control: Determine optimal expansion and differentiation process in controlled cell cultures (pH, DO, temperature, stirring speed) of iPSCs and derivatives with consistent, serum-free, xeno-free iPSC expansion medium and 3-hour sterility checkpoints in 100-250mL cultures
  • Automation: Minimize manual time with a multi-parallel platform and walkaway automation advanced flow cytometry and continuous live-cell analysis platforms
  • At-scale throughput: Optimize in 1-8 bioreactors operated in parallel and characterize cells in suspension and adherent cells in 96- and 384-well plates
  • Extensive characterization: Acquire differentiation marker information using advanced flow cytometry and detect morphological changes during differentiation using continuous live-cell analysis
  • Process insight: Gain rapid understanding of the optimal expansion and differentiation protocol by analyzing process parameters and characterization data to correlate CPPs and CQAs
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Ambr® 250 Modular

Expandable automated benchtop bioreactor system with 2-8 single-use 100-250 mL vessels for accelerated, high-throughput PSC process optimization

MODDE®

Design of experiment software to enable a seamless transition from planar to suspension culture while identifying critical process parameters

NutriStem® hPSC XF

Defined, serum-free, xeno-free PSC expansion medium to support expansion of undifferentiated hPSCs. FDA DMF on file

NutriFreez® D10 Cryopreservation Media

Fully defined, serum-free cryopreservation medium for a consistent, high-performance protective environment for PSCs during the freezing, storage, and thawing

Microsart® ATMP

3-hr PCR-based kit for the detection of mycoplasma, bacteria, and fungi for in-process testing of PSC therapeutics

Ambr® 250 Modular

Expandable automated benchtop bioreactor system with 2-8 single-use 100-250 mL vessels for accelerated, high-throughput PSC process optimization

iQue® 3

Advanced high-throughput flow cytometry platform for phenotypic analysis of PSC and PSC derivatives and differentiation tracking

Incucyte® SX5

Automated, real-time, live-cell imaging and analysis platform for quantitative insights into PSC and PSC derivative health, morphology, proliferation and function

MODDE®

Design of experiment software to enable a seamless transition from planar to suspension culture while identifying critical process parameters

iQue® 3

Advanced high-throughput flow cytometry platform for phenotypic analysis of PSC and PSC derivatives and differentiation tracking

Incucyte® SX5

Automated, real-time, live-cell imaging and analysis platform for quantitative insights into PSC and PSC derivative health, morphology, proliferation and function

Ambr® 250 Modular

Expandable automated benchtop bioreactor system with 2-8 single-use 100-250 mL vessels for accelerated, high-throughput PSC process optimization

MODDE®

Design of experiment software to enable a seamless transition from planar to suspension culture while identifying critical process parameters

Incucyte® SX5

Automated, real-time, live-cell imaging and analysis platform for quantitative insights into PSC and PSC derivative health, morphology, proliferation and function

iQue® 3

Advanced high-throughput flow cytometry platform for phenotypic analysis of PSC and PSC derivatives and differentiation tracking

SIMCA®

Powerful multivariate data analysis tool with interactive visualizations, an intuitive interface, and automatable workflows for comprehensive process understanding

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