Don’t compromise your ambition.

At Sartorius, we know every detail of the CAR-T development workflow counts. We believe your ambition is to achieve the highest quality results every day: results that are reproducible, publishable, and actionable, resulting in breakthrough therapy. That’s why we strive to provide innovative solutions, from biomarker identification to production.  We want to ensure you develop the safest CAR-T product, with the highest levels of productivity at every step, and that you never compromise your ambition.

Recent FDA & EMA approvals of CAR-T cell therapies (Kymriah®, Yescarta®) have revolutionized the available therapeutic landscape and given new hope to patients, the medical field, and the research community. To achieve the necessary efficacy and safety for approval of a CAR-T cell therapy, researchers must understand their model systems, identify potential therapeutic targets, and evaluate corresponding hits at an unprecedented level, as early as possible.

The discovery and development process has many steps during which results must remain as uncompromised as possible, such as:

  • Early in vitro assays deploying specific tumor cell models
  • Vector choice for viral gene transfer
  • Imaging and flow cytometry to assess biological responses
  • In vivo studies in animals
  • Clinical trials involving human subjects 

False positive and false negative results, as well as random or uncontrollable artifacts, can significantly decelerate the discovery and development process, potentially hindering novel insights. 
The process starts with basic foundational elements like proper pipetting and liquid-handling technique, aseptic cell culture handling, expansion under optimal conditions, and confidence that cultures are free from contaminating agents such as mycoplasma. It doesn’t stop there.  Every detail of the CAR-T therapy discovery and development process benefits from equipment, technology, and assays specifically developed to deliver safety, speed, and productivity.

Sartorius has developed comprehensive and complementary solutions to help you trust your therapy. Read below to learn what solutions are right for your CAR-T therapy discovery and development efforts.

How Sartorius accelerates and provides confidence in your CAR-T discovery & development

  • Safety: in-depth sample analysis, fast and precise viral vector quantification, rapid detection of contaminants
  • Speed: rapid sample acquisition, no-wash assays, optimized reagents, advanced analysis software
  • Productivity: multiparametric measurement of T-cell dependent cytotoxicity, CAR-T cell phenotype, CAR transduction and activation
  • Biologically relevant results: extension of 2D assays to 3D cultures, assays for both adherent (dissociated solid tumor cells) and non-adherent cell lines
  • Cell characterization & QA/QC: continuous phenotypic & functional analysis over time, under aseptic conditions


Advancing next generation therapeutics with real-time, live-cell analysis

Unprecedented advances in medicine are delivering remarkable results for some patients. Recent approvals of CAR T therapies and new approaches in regenerative medicine, for example, exemplify the progress being made. Much work remains, however, to extend the benefits of these game-changing treatment modalities to a larger patient population...

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CAR T-cell Therapy and Bispecific Antibodies: Frontiers in Cancer Immunotherapy

Register now to watch a panel of experts discuss the design, development, and success of CAR T-cell therapy and bispecific antibodies and the potential these therapeutics hold in the fight against various tumor types.

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NEW Editorial Article: Potential of CAR-T Therapies for Solid Tumors

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Discover Our Solutions

In the world of CAR-T research and development, every detail counts. By maximizing the probability of success and minimizing failure rates throughout the R&D process, we ultimately help decrease overall cost and time from bench to bedside.

Whether considering autologous or allogeneic CAR-T therapies, numerous challenges present themselves at the different stages of the CAR-T discovery and development, among them target antigen selection, on-/off-target screening, CAR delivery, appropriate tumor cell lines, animal models and clinical relevance, tumor heterogeneity, immune escape, expansion and persistence, neurotoxicity, and cytokine release syndrome.

To address this high degree of complexity and the inherently ever-evolving nature of cancer biology, Sartorius supports and enables scientists in their quest to develop the next generation of CAR-T therapies by providing solutions to increase speed and throughput, decrease costs, and allow validation of results via multiparametric methods. We improve product safety and increase trust in the global body of knowledge by providing scientific instrumentation (e.g. flow cytometers, imagers) and equipment and consumables (pipettes & tips, detection kits, and more) of the highest quality and peak functionality.

Discover how Sartorius can help you trust your therapy and have confidence throughout your CAR-T development process with a portfolio that ranges from basic foundational tools, such as pipettes and mycoplasma detection kits, to elegant and intricate technologies, such as real-time non-perturbing cell analysis, flow-based virus characterization requiring minimal sample volumes, and GMP-compliant cell expansion platforms.

IncuCyte® Live-Cell Analysis System

Enables real-time, automated imaging and analysis of CAR-T cell homing (chemotaxis), activation and function, directly from the incubator over days, w...

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ique3 advanced flow cytometry platform

Intellicyt® iQue3

A high throughput, CAR-T cell analysis platform for rapidly profiling cell phenotype and function in cell therapy workflows.

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Your pipette can be an extension of your hand, and is one of the most used (and most personal) tools in your laboratory.  Manual and electronic p...

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MYCAP® CCX Cell Expansion System

Combining integral tubing for aseptic fluid transfer and our unique gas exchange cartridge to support cell growth means you can expand cultures in sha...

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Microsart® ATMP Rapid Real-time PCR Mycoplasma/Bacterial Detection Kit...

Providing fast contaminant detection during CAR-T discovery & development for increased safety. Rapid, highly specific & sensitive method...

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Virus Counter® Platform

CAR-T viral vector quantification has never been easier or faster.  Assess the quality and quantity of viral materials with minimal sample prepar...

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BIOSTAT RM TX Bioreactor

Enables ex vivo expansion of autologous T-cells, while facilitating process development.

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