Sartorius Screening Ensemble for Cell-based Therapies
One in five cell-based therapy producers say that the complexity of developing therapies is their biggest challenge. Finding methods to quickly simplify the complex will be critical to making these potentially lifesaving therapies more accessible to patients. The quality of final product and culture conditions are deeply intertwined, requiring scientists to screen and validate each new condition – changes in raw materials or process parameters, for example – that enters the production process. Conventional methods and technologies in early-stage process development can limit design space and exploration slowing down progress.
We designed the Sartorius Screening Ensemble to enable scientists to screen multiple components at once, characterize both the product and the process early in development, and deliver the flexibility and speed needed to develop the next generation of cell-based therapies.
Acquire
Find the optimal growth conditions by comprehensively screening media, reagents, and clones
Analyze
Generate actionable process data by bringing together process and product characterization to set the stage for process optimization
Apply
Build the foundation to acquire process knowledge for the development of clinically translatable protocol
Accelerate Your Development With Expanded Screening Capabilities
Ambr® 15 Cell Culture
Multiparallel High-Throughput Bioreactor
- Configured for standard temperature range or extended temperature range (cooled system)
- Parallel operation of 24 or 48 microbioreactors, each with 10 – 15 mL working volume
- Automated liquid handling
MODDE®
Intuitive DOE Software
- Design of Experiments (DOE) is the fastest and most cost-efficient way to design effective experiments and increase productivity
- Provides full flexibility and advanced tools for complex and varied investigations alongside an intuitive design wizard making it the perfect tool across experience levels
- Make the most of valuable samples, raw materials, and human resources by enabling data-driven decision making
SIMCA®
Multivariate Data Analysis Software
- SIMCA® provides a comprehensive toolbox for data mining, multivariate data analysis (MVDA), and model interpretation
- Build robust models from historical data, carry out systematic investigations to discover sources of variability and predict future behavior to proactively avoid problems
- Create informative data visualizations to extract and communicate insights quickly and effectively
4Cell® Nutri-T | MSC NutriStem® XF | NutriStem® hPSC XF
Xeno-free, serum-free media formulated to achieve excellent yield
- Xeno-free, serum-free; serum addition is not required to achieve excellent yield
- Excellent performance with low initial seeding concentrations
- Manufactured in accordance with ISO 13408 guidelines
CellGenix® Preclinical Growth Factors and Cytokines
Exceptional batch-to-batch consistency purity and sterility
- Lyophilized for a longer shelf life
- Animal component free
- Seamless transfer to GMP
SoloHill® Microcarriers
Promotes excellent cell line attachment and growth with conditioning needed
- Size range from 90 – 212 µm
- Xeno-free or animal protein coated options
- Currently used in FDA approved therapies
Incucyte® SX5
Continuous Live-Cell Imaging
- Our most advanced offering, with swappable optical modules and new applications like lab-tested protocols and purpose-built, intuitive software
- Culture, manipulate, and assay in parallel
- Up to 5 different fluorescent channels, up to 3 simultaneously plus HD Phase Imaging
- Support for 3 interchangeable vessel trays and over 600 vessels, up to 6 microplates in parallel
iQue® 3
Advanced High Throughput Flow Cytometry System
- High-throughput flow cytometer with intelligent software to reduce the time to actionable answers
- Precise automated mapping of 384 or 96 well plates allows you to reproducibly use the smallest sample volumes in the industry
- ForeCyt® Software was designed from the ground up to process whole plates of data, creating a simplified, interactive workflow where all the analysis, visualization and interpretation tools are integrated together