The Stainless Steel Fermenter | Bioreactor for Your Laboratory

The BIOSTAT® Cplus is a Sterilizable-In-Place (SIP) Fermenter | Bioreactor developed for the cultivation of microorganisms and cell cultures. Culture vessels with working volumes of 5 L, 10 L, 15 L, 20 L and 30 L are available. With more than a thousand installations worldwide, the BIOSTAT® Cplus is the most successful stainless steel bioreactor of its class and is now available in the revised 3rd generation with DCU controller.

Top Features

  • Choice between electro or steam heating for operation and sterilization; cost-effective integration into existing infrastructure
  • Powerful DCU automation platform with newly added functions, e.g. Advanced DO controller, gravimetric feed control and up to four mass flow controllers allowing more sophisticated gassing strategies
  • Safe to use due to maintenance-free agitator motor and automatic sequences for sterilization and pressure hold test
  • Compact, mobile design saves valuable laboratory space

Ease of Use, Simple Cleaning and a Space-Saving Design

Innovative Technology for Your Process Needs

  • Process development and scale-up
  • Seed production

Maximum working volumes of (in 2:1 and 3:1 diameter ratio):

  • 5 L (benchtop version, only 2:1 ratio)
  • 10 L
  • 15 L
  • 20 L
  • 30 L
  • O2 Enrichment
  • Additive Flow
  • Advanced Additive Flow

Advanced DO Controller
In comparison with the conventional DO control cascade, the Advanced DO Controller supports the sequential and parallel operation of up to 5 slave controllers. The controller can be easily configured using the touch screen. Results are graphically displayed as a polygonal curve, which is easy to understand. As a result, you benefit from maximum flexibility for optimal oxygen regulation in your process.

Cell Cultivation

Predictive Cultivation with BioPAT® Sensors

  • Control glucose level with the local control software of the BIOSTAT® Cplus
  • Automated glucose set point control
  • Establish profiles for the glucose concentration set point
  • Monitor lactate concentration and display data directly on the DCU screen
  • Select up to four variable speed pumps for substrate addition
  • Inline monitoring of total biomass based on turbidity
  • Inline monitoring of total biomass based on capacitance

Microbial Fermentation

Predictive Cultivation with BioPAT® Sensors

  • High precision of gas flow control by intelligent mass flow controllers
  • Real-time monitoring of exhaust gas is directly available in your BIOSTAT® Cplus
  • Facilitate insights into critical metabolic changes during your fermentation process
  • Ensures optimal growth conditions, ultimately increasing the productivity of your process
  • The fully integrated sensor allows multi-variant bioprocess monitoring
  • Provides real-time feedback on the status of your process
  • Multiple parameter monitoring, e.g., nutrients, metabolites, cell parameters and titers
  • Enhanced process parameter control with the help of turbidity measurement
  • Greater process understanding of high cell density fermentations

Downloads

Brochure BIOSTAT® Cplus - English

PDF 2.0 MB

Brochure BIOSTAT® Cplus – German

PDF 2.0 MB

Brochure BIOSTAT® Cplus – Chinese

PDF 2.9 MB

August 25, 2017 | iBET

Application Note: BIOSTAT® Cplus stirred tank bioreactor for microcarriers-based Vero cells culture

PDF | 917.8 KB

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