The Industry Standard Bioreactor for Advanced Process Optimization and Characterization

The BIOSTAT® B-DCU is a fermenter | bioreactor specifically designed to accommodate the requirements of process optimization and characterization in the biotech and biopharmaceutical industry. It provides enhanced functionality and an unrivalled level of options for cell culture and microbial processes making it the ideal scale-down model for your large scale process.

Top Features

Advanced Sensor and Software Integration

Reveal more information about your process and increase manufacturing efficiency and productivity. Facilitate development of advanced, automated process control strategies to improve titer as well as quality and to reduce human error.

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Broad Range of Process Control Strategies

Mimic your large scale process control approach and generate representative data. Benefit from our fully flexible aeration and feeding options.

Connectivity to Supervisory Systems

Easily connect your BIOSTAT® B-DCU to our BioPAT® MFCS or third party supervisory software like DeltaV™. Straightforward integration into existing automation infrastructure provides you with data consistency across scales and throughout the entire development process.

Learn more about BioPAT® MFCS

Industry Standard Technologies

Reliable technologies ensure hassle-free process optimization and characterization. Benefit from our decades of experience in the biopharmaceutical industry.

Fully Configurable

Innovative Technology for Your Process Needs

  • Process development
  • Process optimization
  • Process characterization

Working volumes:

  • UniVessel® Glass 1 L: 0.35 - 1L
  • UniVessel® Glass 2 L: 0.6 - 2 L
  • UniVessel® Glass 5 L: 0.6 - 5 L
  • Univessel® Glass 10 L: 1.5 | 5 - 10 L
  • UniVessel® SU: 0.6 - 2 L

Cell Cultivation

Control of Glucose and Lactate Concentration

  • Control glucose level with the local control software of the BIOSTAT® B-DCU
  • Automated glucose set point control
  • Establish profiles for the glucose concentration set point
  • Monitor lactate concentration directly on the DCU screen
  • Select up to four variable speed pumps for substrate addition

Learn more about BioPAT® Trace

  • Create advanced control loops based on glucose and lactate concentration
  • Develop your specific process strategy for event-based glucose feeds

Learn more about BioPAT® MFCS

Control of Perfusion Processes

  • Operate the BioPAT® Viamass probe without any external software
  • Monitor the viable cell volume directly on the local control screen
  • Make information about the viable cell volume available to supervisory control software

Learn more about BioPAT® ViaMass

  • Implement advanced perfusion control strategies, e.g. via automatic control of feeds and bleeds
  • Robust and reliable determination of time of harvest or transfer of inoculum

Learn more about BioPAT® MFCS

Microbial Fermentations

Metabolic Respiration Control

  • High precision of gas flow control by intelligent mass flow controllers
  • Realtime monitoring of exhaust gas is directly available in your BIOSTAT® B-DCU
  • Facilitate insights into critical metabolic changes during your fermentation process
  • Ensure optimal growth conditions, ultimately increasing the productivity of your process

Learn more about BioPAT® Xgas

  • Obtain an automatic calculation of OUR, CER and RQ
  • Apply reliable, advanced gassing or feeding strategies to improve production rates and reduce cultivation time
  • Receive a complete batch record of O2 | CO2 in the off-gas to reveal more information about your process

Learn more about BioPAT® MFCS

Control of Glucose, Ethanol and Methanol Concentration

  • Monitor glucose, ethanol or methanol level with the local control software of the BIOSTAT® B-DCU
  • Automated glucose set point control
  • Establish profiles for the glucose concentration set point
  • Select up to four variable speed pumps for substrate addition

Learn more about BioPAT® Trace 

  • Create advanced control loops based on glucose, ethanol, or methanol concentration
  • Develop your specific event-based control strategies

Learn more about BioPAT® MFCS


Downloads

BIOSTAT® B-DCU — The Industry Standard Bioreactor for Advanced Process Optimization and Characterization

Precise control of gas flows within the BIOSTAT® B-DCU

PDF | 960.4 KB

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High cell density Escherichia coli fed-batch cultivation in the new BIOSTAT® B-DCU

PDF | 1.1 MB

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Automated Glucose Control

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