Sample Prep for Quality Control
Quality control (QC) is a critical step in the pharmaceutical and biopharmaceutical industry. Every pharmaceutical manufacturer must demonstrate that their products are consistently manufactured, safe, potent, and pure. The number of tests that must be run by QC labs continues to rise to meet the ever increasing QC requirements of global regulatory agencies.
Pharma Compliant Weighing
Sartorius’s Cubis® II is designed to follow US FDA data integrity principles that require data to be accurate, legible, contemporaneous, original, and attributable (ALCOA).
The Cubis® II balance, with pharma package, contains all the technical controls to support full compliance with common regulations.
HPLC sample preparation
Clean samples = clean results
HPLC is one of the most common high-precision analytical methods. Its primary objective: deliver reproducible and specific results. A sample needs to be optimally prepared so it can be injected directly onto an HPLC column.
To accomplish this, your sample not only needs to be dissolved in the appropriate solvent. Even more important, it must also be free of particles to rule out interference in the best possible way during detection and to prevent blockage of your column. This labor-intensive sample prep is often a tedious chore that is time-consuming.
Impact of the Claristep® Filtration System on Recovery and Adsorption of Various Therapeutic Proteins at Low Sample Volumes
We tested the novel filter device Claristep® for the preparation of protein samples containing one of four different biotherapeutics. In comparison to the standard protocols...
Ultrapure Water for HPLC Analysis
The quality of a solvent is often decisive for the reliability of an HPLC analytical run, as the presence of trace contaminants during gradient elution can result in “ghost or phantom peaks.” Deionized or distilled water still contains considerable quantities of organic substances...
Your HPLC results can only be as good as your sample prep quality
Non-optimized Sample Prep
Chromatogram with pronounced background noise and peak tailing
In HPLC analysis, problems originating from sample preparation can occur.
- Possible blockage of your HPLC column
- Lower sensitivity of your HPLC column
- Peak Tailing
- More false-positive peaks
- Higher background noise
Optimized Sample Prep
Chromatogram with a stable baseline and symmetrical peaks
Using Sartorius products to prepare samples for HPLC prevents the usual problems from occurring and permits higher analytical accuracy to be attained.
- No blockage of your HPLC column
- Higher sensitivity of your HPLC column
- Higher accuracy
- Fewer false-positive peaks
- Less background noise
- No leachables
For high sensitivity analyses, every detail counts.
Let us convince you how you can save time with our solutions and at the same time increase the reproducibility of your results:
Innovative Discovery: Fast & Simple
Sample Prep Solutions for HPLC & More
Our analytical sample preparation solutions combine our legendary quality and reliability with our design wisdom to provide the very best in high pressure liquid chromatography (HPLC), liquid chromatography–mass spectrometry, ion chromatography (LC-MS, IC), or inductively coupled plasma mass spectrometry (ICP-MS) filtration solutions.
- Fast, simple, & economical
- Low retention volumes & maximal recoveries
- Almost zero leachables or extractables