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A High-Throughput and Automated Method for AAV Tangential Flow Filtration Process Development

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A High-Throughput and Automated Method for AAV Tangential Flow Filtration Process Development

This Application Note presents a comprehensive approach to developing a high-throughput Tangential Flow Filtration (TFF) process for Adeno-associated virus (AAV) manufacturing, which is crucial for advancing gene therapies. It focuses on optimizing ultrafiltration and diafiltration (UF|DF) processes to enhance efficiency and scalability in AAV production.

Key Takeaways:

  • High-Throughput Screening: Utilized the Ambr® Crossflow system for efficient ultrafiltration and diafiltration (UF|DF) process screening with minimal AAV material.
  • Scalability: Successfully transferred optimized TFF conditions to the larger Sartoflow® Smart system, maintaining consistent results.
  • Efficiency: Accelerated AAV process development, enabling rapid selection of effective ultrafiltration consumables to meet the growing demand for gene therapies.

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