Single-Use Filtration and Liquid Transfer System for Bioprocessing
Flexact® TFI filtration skid
The Flexact® TFI system is a flexible, single-skid solution for automated transfer and filtration. It supports key bioprocess steps including media and buffer preparation, clarification, process filtration and liquid transfer, virus retention, and virus inactivation.
The system supports customized workflows and optimized operational performance, with flexible recipe creation tailored to specific processes and applications.
A powerful recipe editor lets users create and adapt automated workflows, reducing manual handling and ensuring consistent, scalable execution. These flexible recipes enable broad application coverage across upstream and downstream processes, allowing the filtration system to adapt as product pipelines and requirements evolve. Integrated audit trails and batch reports support 21 CFR Part 11-aligned documentation.
The Flexact® TFI system controls flow and pressure with optional automated pinch valves and flexible termination modes, including manual, time-based, and event-based control (triggered by weight, volume, or empty tubing). When combined with RIO-Connect for Palletank®, the system supports advanced monitoring and adjustment of pH, conductivity, temperature, and mixing. An integrated batch reporting system provides electronic records to support documentation aligned with 21 CFR Part 11 requirements.
The Flexact® TFI single-use filtration system is designed for facilities running multiple products. While systems dedicated to individual unit operations can drive up cost and complexity, the Flexact® TFI system offers a simplified alternative. Its fixed yet flexible design space — featuring multiple pump options and modular pressure, flow, and valve configurations — allows one skid to efficiently support a wide range of process needs.
Explore the Flexact® TFI system
The Flexact® TFI system combines process hardware and automation software on a single work platform. Explore how its versatile configuration supports a wide range of upstream and downstream workflows.
Flexact® TFI system overview
The Flexact® TFI system combines pumping and integrated control to simplify liquid transfer and filtration, elevating your fluid management performance.
Flexible software
The Flexact® TFI software enables flexible, recipe-based automation for liquid transfer and filtration processes. An intuitive recipe editor allows users to create, adapt, and execute process-specific workflows using modular control phases. Integrated visualization displays process values, alarms, and system status, while automated data recording, audit trails, and batch reports support documentation aligned with 21 CTR Part 11 principles.
Robust control
The Flexact® TFI system provides robust, automated process control for transfer and filtration operations. It supports flow- and pressure-controlled operation, automated pinch-valve routing, and flexible transition modes — including time-based, and event-based triggers such as pressure, weight, or volume. When combined with RIO Connect for Palletank®, the system enables additional sensor monitoring and control mixing to ensure consistent, repeatable execution.
Reliable monitoring
The Flexact® TFI system supports comprehensive sensor integration for reliable process monitoring and control. Standard and optional sensors include pressure and flow measurement as well as weight-based control. The system can also be combined with RIO-Connect for Palletank® to leverage additional BioPAT® sensors for monitoring pH, conductivity, temperature, and mixing speed. These features support process analytical technology-aligned operation and consistent, data-driven processes.
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Frequently asked questions
The Flexact® TFI system is a flexible, automated single use solution for liquid transfer and filtration. It is designed to support multiple bioprocessing steps on one skid using recipe based automation, helping reduce manual handling while improving process consistency and transparency.
The user can create recipes to automate the Flexact® TFI system across a wide range of upstream and downstream bioprocessing applications, including media and buffer preparation, cell clarification, process filtration and liquid transfer, virus inactivation, and virus filtration (retention).
The system offers automated flow and pressure control, recipe based execution, and centralized visualization of process values, alarms, and system status. This reduces operator workload and variability while supporting reproducible process execution.
Flexact® TFI includes integrated electronic data recording, audit trails, and batch reporting. All process values and user interactions are stored locally on the system, supporting documentation aligned with 21 CFR Part 11 principles.
Yes. The Flexact® TFI system is designed for use with single-use flow kits, filter transfer sets, Palletank® containers, and Flexsafe® solutions. Optional RIO Connect enables integration of additional process signals such as pH, conductivity, and temperature.
