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SARTOFLOW® Smart - The Crossflow System for Process Development

Smart and Easy - Small Scale Benchtop System 

The SARTOFLOW® Smart is a modular and flexible small scale benchtop crossflow system optimized for ultrafiltration and diafiltration applications used in many downstream processes, such as purification of vaccines, monoclonal antibodies and recombinant proteins. The system is suitable for use in laboratory environments for process development and clinical trials as well as for cGMP environments.

>Excellent Flexibility

Ideal for membrane surface areas 
from 50 cm2 to as much as 0.14 m2

Intuitive and User-Friendly

One operating design and predefined sequences for all SARTOFLOW® systems

The Highest Product Yields

Low shear 4-piston membrane pump

One System – Highest Flexibility

The SARTOFLOW® Smart can be configured to accept either Sartocon® Slice 200 or Sartocon® Slice ECO UF cassettes. An optional holding device for 50 cm2 filtration modules e.g. Sartocon® Slice 50 is available. 
The recirculation tank utilizes a load cell for level control and can be replaced by a recirculation bag stand with Flexboy® bags. All control functions are fully operable whether you run the system with a polysulfone (PSU) tank or a single-use bag.

Bag holder & Sartocon® Slice 200

1 L Vessel & Sartocon® Slice 200

1 L Vessel & Sartocon® Slice 50

Bag holder & Sartocon® Slice 50

SARTOFLOW® Smart Overview

Intuitive Operation – Predefined Production Sequences

You can use predefined parameters to automatically run customized sequences for concentration, diafiltration (UF | DF), rinsing, filling, draining, flushing steps and tare functions. This allows intuitive and user-friendly operation.

DCU-4 touch screen

Process Sequences

The following production sequences are provided by the system

Con-Di-Con

Used to concentrate the product to a predefined level and to diafilter the product subsequently - followed by concentration to a final level.

Concentration

Used to concentrate the product to a predefined final level.

Diafi-Conc

Diafiltration of the product. At the end of this phase, the product is concentrated to a predefined volume.

Flushing

Used to rinse the system by flushing the system with WFI, acidic or alkaline solutions.

Drain | harv

Used to drain or harvest the product from the system.

Filling

Used to fill the tank or bag with product.

Weight

Automatically zeros the load cell.

Pressure

Automatically zeros all pressure sensors.

Just select and start the phases on the control panel, and the DCU-4 will then execute the steps automatically. Interactions or process end will be indicated by text messages.

Optional software

  • MFCS/Win Standard software package
  • Recipe Control (S88) software module
  • 21 CFR part 11 software module
  • BioPAT® MFCS | win OPC

SARTOFLOW® Smart — Smart and easy – the crossflow system for process development

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>Sartocon® Slice 50

The ready-to-use 50 cm² crossflow device is the optimal choice for process development of biopharmaceutical solutions with small volumes. Its encapsulated design allows linear scale-up combined with identical material of construction. This eases the data transfer of process development results into the next level.

Sartocon® Slice 50 can easily be interfaced with the SARTOFLOW® Smart system.

Ordering Information

Sartocon® Slice 50 — Small scale process development disposable ultrafilters for biopharmaceutical applications

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