Sartoflow® Smart Small-Scale Benchtop TFF System
Intelligent and Simple — The TFF System for Process Development to GMP
The Sartoflow® Smart is a modular and flexible small-scale TFF benchtop system optimized for ultrafiltration and diafiltration (UF | DF) applications used in many downstream processes, such as purification of vaccines, monoclonal antibodies and recombinant proteins. The system is well-suited to laboratory environments for process development and clinical trials as well as small-batch cGMP production.
Ideal for membrane surface areas from 50 cm2 to 0.14 m2 with optional customization features.
User-friendly with a high level of automation, an automatic retentate valve, and an external feeding pump.
Low-shear 4-piston membrane pump and compact 20 mL recirculation volume for maximum yield.
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Sartoflow® Smart Overview
The Sartoflow® Smart is a modular and flexible small-scale system with many customization options:
- Automated retentate valve
- External diafiltration pump
- Sartocon® Slice 50 cassette holder
- Sensors for pH, conductivity, and temperature
- External permeate balance up to 64 kg (vs. 7 kg as standard)
- Recirculation and | or permeate holder for Flexboy® bags
- IQ | OQ execution package
- Basic qualification test documentation
- cGMP documentation
With an intuitive, user-friendly interface, operators can use predefined parameters to automatically run customized sequences for concentration, diafiltration (UF | DF), rinsing, filling, draining and flushing steps.
The Sartoflow® Smart TFF system is the ideal tool for developers establishing and refining process parameters in scale-up and scale-down studies. Achieve stable values for retentate pressure or TMP by applying the automated retentate valve and diafiltration pump.
- Low minimum sample volume
- Low minimum recirculation volume
- Easy data access
High level of automation for data continuity and reproducibility
Full transferability of process data to large-scale systems
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Frequently Asked Questions
The Sartoflow® Smart system features a 7" touch screen for easy operation, displaying control functions and trend curves. It includes interactive prompts and a logbook for alarms and user logs. The DCU-4 control unit supports communication with Sartorius software for enhanced data logging and process control.
Customization options include different membrane surface areas, automated valves, external pumps, and various sensors. The system can be configured with recirculation and permeate bag holders, and a holder for Sartocon® Slice 50 cassettes, offering flexibility for diverse filtration needs.
The system supports scalability with compatibility for Sartocon® Slice cassettes, offering a wide range of membrane surface areas. Preprogrammed sequences and recipes ensure consistent process execution, enabling easy transition from lab-scale to production-scale operations.
