On-Demand Webinar: Storm Chasing: Cytokine Profiling Flow Cytometry Age-Related Neurodegenerative Diseases
Despite some treatments being available, as our aging population expands, the prevalence of neurodegenerative diseases such as Parkinson's disease, frontal temporal diseases, multiple system atrophy, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Huntington's disease and dementia with Lewy bodies, is growing.
Many neurodegenerative disorders can be characterized by the abnormal formation and aggregation of proteins in the brain, such as tau, alpha-synuclein and amyloid-beta. Increasing evidence reveals the contribution of the immune system in the onset and progression of these diseases.
Establishment of appropriate in-vitro cell models and associated cytokine profiling of cytokine storms, is critical in increasing our understanding of the role of immune cells and inflammatory response in the etiology of neurodegenerative diseases. Techniques to monitor cytokine storms, such as flow cytometry are available.
This webinar details neuroimmune interactions, cells models for the study of disease and also possibilities of the development of therapeutics, which will appreciably delay or prevent progression of neurodegenerative diseases.
- Discussion of the role of the immune system in controlling the central nervous system
- Insights into the role of immune cells in neurodegenerative diseases
- Expansion on the latest findings and novel therapeutics for neurodegenerative diseases
- Exploration of some critical in-vitro laboratory techniques, used in the interrogation of cytokine storms
Louise D. McCullough
Roy M. and Phyllis Gough Huffington Distinguished Chair and Professor of Neurology Department of Neurology, McGovern Medical School
Dr McCullough is recognized for her work in cerebral vascular disease and her research identifying sex differences in cell death pathways during stroke, which are now recognized as major factors in the response to an ischemic insult. Her laboratory also studies aging and inflammation, and how these factors influence recovery after stroke.
Maxim N. Artyomov, Ph.D.
Department of Pathology and Immunology, Washington University School of Medicine
Maxim Artyomov’s laboratory aims to discover novel fundamental biology in the areas of immunometabolism, cancer immunology and aging by using cross-disciplinary approaches to data generation and analysis together with in vitro and in vivo experimental biology. Classically trained immunologists and molecular biologists work hand-in-hand with computational biologists and computer scientists to leverage the power of high-throughput omics datasets. Collectively, this approach can be characterized as Systems Immunology.
Susana Alcantara, Ph.D.
BioAnalytical Applications, Sartorius
Susana L. Alcantara is currently a Principal Scientist and Neuroscience Program leader within the Applications unit of BioAnalytics at Sartorius AG. She is a highly experienced cellular neuroscientist with over 15 years of experience in large pharma drug discovery (GSK), biotech (Essen BioScience) and start-up (Proximagen) R&D settings. Trained initially as a Biochemist & Microbiologist, Susana’s early work focused on translational research models and cellular signalling pathways in neurodegeneration and dyskinesia in Parkinson’s disease.
Within the Sartorius neuroscience team, during the past 11 years, she has developed and validated a wide range of advanced cell assays for neuroscience to extend the suite of applications of live-cell analysis.