Label-Free Technologies for Accurate Determination of Affinity and Kinetics Rate Constants

Application Note

From target molecule identification to lead selection and optimization, equilibrium affinity and kinetics rate constants are critical parameters in the advancement of a potential therapeutic drug through the development cycle.

These parameters enable researches to better understand mechanisms of action (MOA) of the drug candidate against its target as well as provide necessary information in the selection of optimal candidates. In addition to new drug lead molecules, kinetics characterization is also critical in comparing biosimilar molecules to their originator counter parts.

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