The AAA-ATPase p97 is an essential protein involved in numerous cellular processes and plays a key role in multiple aspects of protein homeostasis. Its functional diversity is mediated through the interaction with many distinct cofactors. Due to its significant role in regulating a variety of physiological responses, p97 has emerged as a potential therapeutic target. In this webinar, Sebastian Bothe from the University of Würzburg will present a combined approach that exploits computer-based methods, including virtual screening of molecular databases and biochemical/biophysical techniques.
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Watch this webinar on demand to learn more about:
- How to select potential candidates
- The use of Bio-Layer Interferometry (BLI) for fragment screenings
- Developing label-free assays for small molecule characterization
- Optimizing the measurement of small molecule inhibitors