The AAA-ATPase p97 is an essential protein involved in numerous cellular processes and plays a key role in multiple aspects of protein homeostasis. Its functional diversity is mediated through the interaction with many distinct cofactors. Due to its significant role in regulating a variety of physiological responses, p97 has emerged as a potential therapeutic target. In this webinar, Sebastian Bothe from the University of Würzburg will present a combined approach that exploits computer-based methods, including virtual screening of molecular databases and biochemical/biophysical techniques.

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Watch this webinar on demand to learn more about:

  • How to select potential candidates
  • The use of Bio-Layer Interferometry (BLI) for fragment screenings
  • Developing label-free assays for small molecule characterization
  • Optimizing the measurement of small molecule inhibitors

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The webinar speakers:

Sebastian Bothe
PostDoc, Department of Biochemistry, University of Würzburg, Germany

Dr. Helge Schnerr
Global Campaign Manager, Sartorius

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