Sartorius T-Cell Optimization and Characterization Solution
Scaled-up, semi-automated solution to gain process insight through CPP and CQA correlation for the development of a robust CAR-T manufacturing protocol
- Process control: Determine optimal growth performance and identify critical process parameters with consistent, serum-free, xeno-free T-cell medium and rapid sterility testing in volumes from 100mL to 250mL
- Automation: Rapidly carry out process development and process optimization with minimal manual handling and online semi-automated monitoring as well as functional and phenotypic characterization of CAR-T cells
- At-scale throughput: Optimize expansion process in 1-8 bioreactors operated in parallel and perform multiplex analysis in 96- and 384-well plates
- Extensive characterization: Test for CAR-T phenotypes and functions with multiplex analysis of cells in suspension and profiling in T-cell killing and T-cell health assays
- Process insight: Analyze process parameters and characterization data in order to correlate CPPs and CQAs
Ambr® 250 Modular
Expandable automated benchtop bioreactor system with 2-8 single-use 100-250 mL vessels
4Cell® Nutri-T
Xeno-free, serum-free medium specifically designed for the culture and expansion of lymphocytes
MODDE®
Design of experiment software to facilitate translation of data to insights and shift process complexity from the floor to the control room
Microsart® ATMP
3-hr PCR-based kit for the detection of mycoplasma, bacteria, and fungi for in-process and rapid release testing of cell-based therapeutics
Ambr® 250 Modular
Expandable automated benchtop bioreactor system with 2-8 single-use 100-250 mL vessels
MODDE®
Design of experiment software to facilitate translation of data to insights and shift process complexity from the floor to the control room
Incucyte® SX5
Automated, real-time, quantitative, live-cell imaging and analysis platform for T-cell homing (chemotaxis), activation and function assays
iQue® 3
High-throughput, advanced flow cytometry platform for T-cell activation and cytokine profiling assays as well as multiplexed phenotypic analysis
Ambr® 250 Modular
Expandable automated benchtop bioreactor system with 2-8 single-use 100-250 mL vessels
MODDE®
Design of experiment software to facilitate translation of data to insights and shift process complexity from the floor to the control room
iQue® 3
High-throughput, advanced flow cytometry platform for T-cell activation and cytokine profiling assays as well as multiplexed phenotypic analysis
Incucyte® SX5
Automated, real-time, quantitative, live-cell imaging and analysis platform for T-cell homing (chemotaxis), activation and function assays
Incucyte® SX5
Automated, real-time, quantitative, live-cell imaging and analysis platform for T-cell homing (chemotaxis), activation and function assays
iQue® 3
High-throughput, advanced flow cytometry platform for T-cell activation and cytokine profiling assays as well as multiplexed phenotypic analysis
SIMCA®
Powerful multivariate data analysis tool with interactive visualizations, an intuitive interface, and automatable workflows for comprehensive process understanding
