Sartorius T-Cell Exploration and Characterization Solution
Miniaturized, high-throughput, semi-automated solution to acquire in-depth process knowledge through correlation of CPPs and CQAs to identify and optimize CAR-T cells
Process control: Control pH, DO, temperature, and stirring speed to optimize culture performance for the selected CAR-T cells using consistent, serum-free, xeno-free T-cell medium along with sterility checkpoints in 15 mL culture vessels
Automation: Pre-design experimental setup using DoE software and screen intelligently for optimal expansion conditions to select for specific functional and phenotypic characteristics of CAR-T cells
At-scale throughput: Acquire process information using 24-48 vessel multi-parallel screening platform as well as perform cell analysis in 96- and 384-well plates
Extensive characterization: Perform T-cell activation, cytokine profiling, T-cell killing, and T-cell health assays with multiplex analysis of cells in suspension and continuous live-cell analysis of cultures
Process insight: Develop overall process understanding through the integration of culture performance as well as phenotypic and functional characterization using advanced analytics
Process Control
4Cell® Nutri-T
Xeno-free, serum-free medium specifically designed for the culture and expansion of lymphocytes
Automation
MODDE®
Design of experiment software to facilitate translation of data to insights and shift process complexity from the floor to the control room
At-Scale Throughput
MODDE®
Design of experiment software to facilitate translation of data to insights and shift process complexity from the floor to the control room
Extensive Characterization
Process Insight
SIMCA®
Powerful multivariate data analysis tool with interactive visualizations, an intuitive interface, and automatable workflows