Cell Line & Cell Culture Services
Optimize Your Cell Line and Media With Our Experts and Comprehensive Services.
The right cell culture media is unique to your process, and finding the right one ensures that your cell line will meet its full potential from start to scale-up.
Our team streamlines your media development and optimization with comprehensive media services combined with decades of industry experience. We can rapidly deliver proof-of-concept for your process, develop a platform approach to ensure efficiency, and give you access to our portfolio of high-performing, chemically defined, and robust cell culture media.
Achieve your desired process performance indicators by relying on our iterative media development process with expert-to-expert interactions.
Get data & process insights quickly with the fastest turnaround time for sample analysis.
Simplify and expedite production scale-up; all our formulations are scalable-by-design to easily move from prototype, pilot, to for-further-manufacturing use media with installed global manufacturing capabilities.
Explore Our Media Services
Benchmarking Studies for Viral Vector and Protein Production
Selecting the right cell culture media and feed usually involves screening and benchmarking multiple off-the-shelf culture media across several suppliers.
With our extensive experience in cell culture technologies and media development, we offer expertise and resources to help you perform these routine studies. Our media portfolio is benchmarked against your reference medium in your defined HEK- or CHO-based processes to improve overall performance.
Media Optimization to Unlock Process Efficiency
Understanding your process is key to streamlining development and reducing time-to-market. Your process parameters, cells, and cell culture media interact in unique ways to define the productivity and quality of the protein or viral vector output. Optimizing your process based on our media formulations can further improve titer, product quality, and unlock productivity gains.
We leverage integrated analytical testing to uncover process insights, validate in benchtop bioreactors, and work closely with your team to ensure seamless process transfer and scale-up.
Achieve the titer and product quality you need: Our team works in-house to deliver optimized media that’s as unique as your process.
- We perform process optimization using our Ambr® bioreactor system.
- Your team & ours share and discuss interim data to decide on next steps.
- We confirm the optimized process in a benchtop bioreactor to ensure easy process transfer and scale-up.
Targeted and Efficient Services for Developing New and Customized Cell Culture Media and Feeds
In close collaboration, we together carefully choose individual target values for process performance based on your application – including titer, cell viability, concentration, and more. Following a streamlined workflow, we combine powerful spent media analysis with intelligent design of experiment (DoE) and process simulations to meet your needs.
- Starting from scratch and individual compounds, each cycle feeds the following one with insights
All the media and feed products you will receive are chemically defined and animal-derived component-free
Once the formulation is developed, you can select amongst flexible solutions to bring your formulation to powder production; available packaging solutions range from liquid in single-use bags from 100 mL to 1,000 L, and powders
The media & process expertise you’ll get includes the most common cell lines (CHO, HEK, hybridoma, MDCK, BHK21) and more! Our targets include protein production, viral, and viral vector production (Adeno-Associated Viruses (AAV) and Lentivirus (LV) production for gene and gene-modified cell therapy applications).
Optimize Your Cell Line Performance and Reduce Variability With Our Fresh & Spent Media Analytics Services
Media analytics capabilities are utilized in every media benchmarking study, media optimization or media development project so you get consistent, reliable, and advanced data for decision making.
Reach new heights of process insights
Targeted analytics are conventional methods for amino acids, vitamins, and trace elements. Use them for process insights and routine monitoring.
Untargeted analytics is an innovative and holistic method for root cause analysis which you may use for exploration or batch-to-batch variability. You will be able to make decisions based on statistical models and multivariate data analysis (MVDA) via principal component analysis (PCA) and visualize the data as our experts walk you through the results.
Benefit from 60+ validated methods (according to ICH and executed according to EP | USP) to give you valuable insight across your biomanufacturing process steps.
Depending on the samples, our data report turnaround time can be as short as five business days.
Find Out How Screening, Optimization and Development Services Compare To Match Your Needs.
Benchmarking Study | Media Optimization Service | Media de novo Development Service | |
|---|---|---|---|
| Comparability data from screening against proprietary media library |
|
|
|
| Ad-hoc experts-to-experts interactions and decision | |||
| Improve your formulation based on current process conditions | |||
| Gain insights with analytics and spent media analysis | |||
| Benefit from a comprehensive development service from scratch | |||
| Access to small quantities for in-house confirmation runs | |||
Ensuring media formulation scalability for further manufacturing use |
|
|
|
Cell Line and Cell Culture Adaptation
We help you scale up your process by overcoming adherent culture limitations and finding the optimal animal-component-free media for your needs.
Learn More About Cell Line & Media Services
Related Assets
A Comprehensive Guide to Finding the Right Cell Culture Media for Your Bioprocesses
PDF | 2.1 MB
