eBook: Functional Profiling of Immuno and Cell-Based Therapies


The field of immunotherapy is acquiring a dominance. Within immuno-oncology (I-O), therapeutic and diagnostic antibodies are joined by T cells engineered with receptors that recognize tumors, and checkpoints preventing target recognition are being overridden. In addition, monoclonal antibodies (mAbs) and their variants, are mitigating autoimmune disorders and treating COVID-19.

Flow cytometry has long been the workhorse of immunology. Yet traditional flow cytometry can be a laborious and time-consuming process, offering low-throughput acquisition.

A fast, easy to use, high-throughput, multiplex platform, which uses minimal sample volumes, to query cells for phenotype, health and proliferation, as well as protein (cytokine) production, is desirable. 

The articles in this eBook provide a taste for some I-O toolbox essentials with the iQue® Advanced Flow Cytometry Platform and associated reagent kits. The iQue® Advanced Flow Cytometry Platform removes the data analysis bottlenecks inherent in traditional flow cytometry, hence providing for fast, easy, high throughput I-O drug discovery, development, and manufacturing quality control.

Page count:
Read time: 2 hours
Target audience: Immunologists, Immuno-oncologists, Virology Researchers, Neuroscientists, Cancer Immunotherapy Drug Discovery Researchers, in biotechnology, pharmaceuticals, biopharmaceuticals, contract research organizations, research institutes, clinical laboratories and academia.     

Key Takeaways

The eBook includes the following chapters from experts in the field:

  1. Using Advanced Flow Cytometry to Analyze Immuno-Oncology Therapeutics
  2. Utilizing Mixed Lymphocyte Reaction (MLR) to Evaluate Checkpoint Inhibitor Therapies by Advanced Flow Cytometry
  3. Quantitative Analysis of CAR-T Cell Exhaustion Using Advanced Flow Cytometry
  4. Quantification of Antibody-Dependent Cellular Phagocytosis via a Streamlined Advanced Flow Cytometry Workflow
  5. Phenotypic and Functional Characterization of CAR-T Cells with Advanced Flow Cytometry and Live-Cell Analysis
  6. Resistance to CAR-T Cell Therapy

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