Natural Killer Cells (NK cells)
Natural killer cells (NK cells) belong to the recently discovered family of innate lymphoid cells (ILCs) and are a subset of cytotoxic lymphocytes involved in the innate immune system. They play an important role in the defense against tumors and virus-infected cells by releasing cytotoxic granules containing perforin and granzymes to directly lyse cells. NK cells act independently of antigen processing and presentation, allowing them to be easily activated and act rapidly. NK cells also produce pro-inflammatory cytokines such as interferon-gamma (IFN-γ). Immunotherapy based on NK cell infusions is a potential adjuvant treatment for many cancers.
To ensure a seamless transition from preclinical development to commercial manufacturing, we offer CellGenix® cytokines and growth factors both in GMP and preclinical grade.
Our GMP cytokines are provided with documented evidence of purity, potency, consistency and stability. In combination with our expert regulatory and technical support this will help simplify your raw material qualification and validation efforts.
CellGenix® GMP recombinant cytokines are produced following all applicable GMP guidelines and allow for the safe use in accordance with USP Chapter <1043>, Ph. Eur. General Chapter 5.2.12 and ISO 20399:2022.
Test Growth Factor and Cytokines Samples for NK Cells
Samples for cell and gene therapy as well as regenerative medicine.
| NK Growth Factors and Cytokines | ||
|---|---|---|
| IL-2 | More Info | Visit eShop |
| IL-7 | More Info | Visit eShop |
| Flt-3L | More Info | Visit eShop |
| SCF | More Info | Visit eShop |
| TPO | More Info | Visit eShop |
| IL-15 | More Info | Visit eShop |
| IL-21 | More Info | Visit eShop |
| IL-6 | More Info | Visit eShop |
| IL-12 | More Info | Visit eShop |
| IL-18 | More Info | Visit eShop |
IL-2
CellGenix® Recombinant Human Interleukin-2 (IL-2) is an animal-derived component-free product. It reliably activates and expands T cells, natural killer cells (NK cells) and cytokine-induced killer cells (CIK cells). CellGenix® rh IL-2 preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
General Information
IL-2 is a cytokine signaling molecule that is mainly produced by T cells. It is a central regulator of immune responses and plays a role in anti-inflammatory reactions, hematopoiesis and tumor surveillance.
IL-2 is used in the cell and gene therapy space to promote proliferation and differentiation of CAR T cells, TCR T cells, Tregs, TILs, NK cells and CIK cells.
IL-7
CellGenix® Recombinant Human Interleukin-7 (IL-7) is an animal-derived component-free product. It supports the survival, proliferation and differentiation of T cells and enhances survival of natural killer cells (NK cells). CellGenix® rh IL-7 preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
General Information
IL-7 is a cytokine that promotes the differentiation of pluripotent hematopoietic stem cells (HSCs) into lymphoid progenitor cells. Furthermore, it supports proliferation of various cells in the lymphoid lineage (B cells, T cells and NK cells). It is secreted mainly by stromal cells in the bone marrow and thymus.
IL-7 is used in the cell and gene therapy space for the ex vivo expansion of genetically modified T cells, such as CAR T cells, and differentiation of induced pluripotent stem cells (iPSCs) into T cells. It is in addition used to differentiate cord blood derived hematopoietic stem cells (HSCs/CD34+) into NK cells.
Flt-3L
CellGenix® Recombinant Human FMS-like Tyrosine Kinase 3 Ligand (Flt-3L) is an animal-derived component-free product. It reliably supports the proliferation of hematopoietic stem cells (HSCs). CellGenix® rh Flt-3L preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
General Information
Flt-3L is a cytokine that regulates proliferation and differentiation of various blood cell progenitors.
Flt-3L is used in the cell and gene therapy space for the ex vivo expansion of HSCs that are used for transplantation.
SCF
CellGenix® Recombinant Human Stem Cell Factor (SCF) is an animal-derived component-free product. It reliably supports survival and differentiation of hematopoietic stem cells (HSCs) and progenitor cells as well as the differentiation of cord blood-derived CD34+ cells into natural killer cells (NK cells). It is also used to differentiate embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into megakaryocytes and T cells. CellGenix® rh SCF preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
General Information
SCF is a cytokine that is produced by fibroblasts and endothelial cells. It plays an important role in hematopoiesis, spermatogenesis and melanogenesis.
SCF is used in the cell and gene therapy space for the expansion of HSCs that are used for transplantation.
TPO
CellGenix® Recombinant Human Thrombopoietin (TPO) is an animal-derived component-free product. It reliably supports the self-renewal and maintenance of hematopoietic stem cells (HSCs) as well as the differentiation of HSCs into natural killer cells (NK cells). It is also used to differentiate embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into megakaryocytes. CellGenix® rh TPO preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
General Information
TPO is a glycoprotein hormone produced by the liver and kidney. It regulates the production of platelets and stimulates the production and differentiation of megakaryocytes.
TPO is used in the cell and gene therapy space for the ex vivo expansion and differentiation of HSCs.
IL-15
CellGenix® Recombinant Human Interleukin-15 (IL-15) is an animal-derived component-free product. It promotes the proliferation of T cells and stimulates the proliferation of natural killer cells (NK cells) as well as the generation of cytokine-induced killer cells (CIK cells). CellGenix® rh IL-15 preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
General Information
IL-15 is a cytokine that plays an important role in humoral and adaptive immune responses. It induces or enhances the differentiation, maintenance, or activation of NK cells and multiple T cell subsets. IL-15 is produced by a large number of cell types, including monocytes, macrophages, dendritic cells, keratinocytes, fibroblasts and nerve cells.
IL-15 is used in the cell and gene therapy space for the ex vivo expansion of various T cells (CAR T cells, TCR T cells and TILs) as well as NK cells and the generation of CIK cells.
IL-21
CellGenix® Recombinant Human Interleukin-21 (IL-21) is an animal-derived component-free product. It reliably promotes the proliferation of T cells and natural killer cells (NK cells) and enhances their cytotoxic function. CellGenix® rh IL-21 preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
General Information
IL-21 is a cytokine that plays an important role in humoral and adaptive immune responses. It stimulates the proliferation of NK cells and multiple T cell subsets, especially cytotoxic T cells. It is produced by activated CD4+ T helper cells and NK T cells.
IL-21 is used in the cell and gene therapy space for the ex vivo expansion of T cells, including CAR T cells and TCR T cells and NK cells.
IL-6
CellGenix® Recombinant Human Interleukin-6 (IL-6) is an animal-derived component-free product. It reliably stimulates the maturation of immature to mature dendritic cells (DCs) and promotes the proliferation of cord blood derived hematopoietic stem cells (HSCs/CD133+ cells). CellGenix® rh IL-6 preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
General Information
IL-6 is a multifunctional cytokine that acts both pro-inflammatory and anti-inflammatory. It regulates acute phase responses, inflammatory reactions, hematopoiesis, bone metabolism, cancer progression and immune responses. It is produced primarily by T cells, monocytes and macrophages.
IL-6 is used in the cell and gene therapy space for the ex vivo maturation of immature DCs and proliferation of HSCs.
IL-12
CellGenix® Recombinant Human Interleukin-12 (IL-12) is an animal-derived component-free product. It promotes the proliferation of natural killer cells (NK cells) and stimulates the differentiation of naive T cells towards Th1 effector cells.
General Information
IL-12 is a cytokine that plays a crucial role in the regulation of immune responses. It is primarily involved in the differentiation of naive CD4+ T cells into Th1 cells and enhances the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes. IL-12 is produced by activated antigen-presenting cells, such as dendritic cells and macrophages.
IL-12 is used in the cell and gene therapy space for the ex vivo activation and expansion of T cells, including for CAR-T cell, NK cell, and TCR therapies.
CellGenix® Recombinant Human IL-12 is produced using Chinese Hamster Ovary cells (CHOSI). By using CHOSI, we are able to produce this difficult to express glyco-protein with authentic human post-translational modifications. These human post-translational modifications are not accessible by bacterial expression.
IL-18
CellGenix® Recombinant Human Interleukin-18 (IL-18) is an animal-derived component-free product. It reliably promotes the proliferation of natural killer (NK) cells.
General Information
Interleukin-18 (IL-18) is a cytokine that plays a significant role in both innate and adaptive immune responses. It is involved in the induction of cell-mediated immunity following infection with microbial products. IL-18 enhances the activity of NK cells and T cells, in particular, by promoting their production of interferon-gamma (IFN-γ). It is produced by activated macrophages and other cell types.
IL-18 is used in the cell and gene therapy space for the ex vivo activation and expansion of T cells, including for CAR-T cell, NK cell, and TCR therapies.
