Mesenchymal Stem Cells (MSCs)
Mesenchymal stem cells (MSCs) are multipotent, with the ability to differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes and adipocytes. In addition, MSCs can also be recruited to excrete cytokines that help in cell repair, metabolism, and reducing inflammation in response to inflammatory signals. Given this remarkable versatility, MSCs offer great therapeutic potential in the fields of cell–based tissue engineering and regenerative medicine. Because they can generate immune-evasive secretions and immunomodulatory factors these cells have an intrinsic advantage for cell therapy application. Currently, these stem cells are being used for the prevention or treatment of graft versus host disease (GvHD) following allogeneic blood stem cell transplantation. The immunomodulatory properties of MSCs can also be employed in autoimmune diseases like diabetes and Crohn’s disease.
To ensure a seamless transition from preclinical development to commercial manufacturing, we offer CellGenix® cytokines and growth factors both in GMP and preclinical grade.
Our GMP cytokines are provided with documented evidence of purity, potency, consistency and stability. In combination with our expert regulatory and technical support this will help simplify your raw material qualification and validation efforts.
CellGenix® GMP recombinant cytokines are produced following all applicable GMP guidelines and allow for the safe use in accordance with USP Chapter <1043>, Ph. Eur. General Chapter 5.2.12 and ISO 20399:2022.
Test Growth Factor and Cytokines Samples for MSC Cells
Samples for cell and gene therapy as well as regenerative medicine.
| Mesenchymal Stem Cell (MSC) Growth Factors and Cytokines | ||
|---|---|---|
PDGF-BB | More Info | Visit eShop |
FGF-2 | More Info | Visit eShop |
TGF-β1 | More Info | Visit eShop |
EGF | More Info | Visit eShop |
PDGF-BB
CellGenix® Recombinant Human Platelet-Derived Growth Factor-BB (PDGF-BB) is an animal-derived component-free product. It reliably supports proliferation of mesenchymal stem cells (MSCs) and chondrocytes. CellGenix® rh PDGF-BB preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
General Information
Platelet-derived growth factor-BB (PDGF-BB) is a member of the platelet-derived growth factor family. It is produced by platelets and plays an important role in angiogenesis.
PDGF-BB is used in the cell and gene therapy space for the expansion of bone marrow and adipose tissue derived MSCs and chondrocytes.
FGF-2
CellGenix® Recombinant Human Fibroblast Growth Factor-2 (FGF-2, also known as bFGF)is an animal-derived component-free product. It reliable improves proliferation of mesenchymal stem cells (MSCs). It in addition supports proliferation and differentiation of chondrocytes and supports propagation of undifferentiated pluripotent stem cells (PSCs). CellGenix® rh FGF-2 preclinical grade and GMP grade are both produced in a dedicated GMP facility.
General Information
Fibroblast Growth Factor-2 (FGF-2) is a basic fibroblast growth factor. It amongst others plays an important role in wound healing and tumor development by mediating the formation of new blood vessels.
FGF-2 is used in the cell and gene therapy space for the expansion of bone marrow and adipose tissue derived MSCs.
TGF-β1
CellGenix® Recombinant Human Transforming Growth Factor-beta 1 (TGF-β1) is an animal-derived component-free product. It reliably promotes the expansion of induced pluripotent stem cells (iPSC), embryonic stem cells (ESC), mesenchymal stem cells (MSC) as well as regulatory T cells (Tregs). It also stimulates the differentiation of T cells into Tregs. CellGenix® rh TGF-β1 preclinical grade and GMP grade are both produced in a dedicated GMP facility.
General Information
TGF-β1 is a member of the growth factor beta superfamily and plays a role in various cellular functions like cell differentiation, proliferation and apoptosis. It is secreted by most immune cells and especially interacts with T cells, B cells, macrophages and monocytes.
TGF-β1 is used in the cell and gene therapy space to promote expansion of iPSC, ESC, MSC and Tregs.
CellGenix® Recombinant Human TGF-β1 is produced using a human amniocyte cell line (CAP®). By using the CAP® technology we are able to produce this difficult to express glyco-protein with authentic human post-translational modifications. These human post-translational modifications are not accessible by bacterial expression.
EGF
CellGenix® Recombinant Human Epidermal Growth Factor (EGF) is an animal-derived component-free product. It reliably promotes the expansion of mesenchymal stem cells (MSCs). It in addition promotes the differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)-derived hepatoblasts. CellGenix® rh EGF preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
General Information
EGF is a growth factor that promotes cell growth, proliferation and differentiation. It is found in a variety of human body fluids.
EGF is used in the cell and gene therapy space for the expansion of bone marrow and adipose tissue derived MSCs, and the generation of stem cell derived hepatocytes.
