Mesenchymal Stem Cells (MSCs)
Mesenchymal stem cells (MSCs) are multipotent, with the ability to differentiate into a variety of cell types, including osteoblasts, chondrocytes, myocytes and adipocytes. In addition, MSCs can also be recruited to excrete cytokines that help in cell repair, metabolism, and reducing inflammation in response to inflammatory signals. Given this remarkable versatility, MSCs offer great therapeutic potential in the fields of cell–based tissue engineering and regenerative medicine. Because they can generate immune-evasive secretions and immunomodulatory factors these cells have an intrinsic advantage for cell therapy application. Currently, these stem cells are being used for the prevention or treatment of graft versus host disease (GvHD) following allogeneic blood stem cell transplantation. The immunomodulatory properties of MSCs can also be employed in autoimmune diseases like diabetes and Crohn’s disease.
To ensure a seamless transition from preclinical development to commercial manufacturing, we offer CellGenix® cytokines and growth factors both in GMP and preclinical grade.
Our GMP cytokines are provided with documented evidence of purity, potency, consistency and stability. In combination with our expert regulatory and technical support this will help simplify your raw material qualification and validation efforts.
CellGenix® GMP recombinant cytokines are produced following all applicable GMP guidelines and allow for the safe use in accordance with USP Chapter <1043>, Ph. Eur. General Chapter 5.2.12 and ISO 20399:2022.
Test Growth Factor and Cytokines Samples for MSC Cells
Samples for cell and gene therapy as well as regenerative medicine.
| Mesenchymal Stem Cell (MSC) Growth Factors and Cytokines | ||
|---|---|---|
PDGF-BB | More Info | Visit eShop |
FGF-2 | More Info | Visit eShop |
TGF-β1 | More Info | Visit eShop |
EGF | More Info | Visit eShop |
PDGF-BB
CellGenix® Recombinant Human PDGF‑BB (rh PDGF‑BB) is an animal component–free growth factor that supports proliferation of mesenchymal stem cells (MSCs) and chondrocytes. Both preclinical and GMP grades are produced in a dedicated animal-free GMP facility.
PDGF‑BB, produced by platelets, is key in angiogenesis and is used in cell and gene therapy to expand bone marrow– and adipose-derived MSCs and chondrocytes.
FGF-2
CellGenix® Recombinant Human FGF‑2 (rh FGF‑2, also known as bFGF) is an animal component–free growth factor that enhances proliferation of mesenchymal stem cells (MSCs), supports chondrocyte proliferation and differentiation, and maintains undifferentiated pluripotent stem cells (PSCs). Both preclinical and GMP grades are produced in a dedicated GMP facility.
FGF‑2 plays a key role in wound healing and tumor development by promoting angiogenesis and is used in cell and gene therapy for expansion of bone marrow– and adipose-derived MSCs.
TGF-β1
CellGenix® Recombinant Human TGF‑β1 (rh TGF‑β1) is an animal component–free cytokine that supports expansion of iPSCs, ESCs, MSCs, and regulatory T cells (Tregs) and drives T cell differentiation into Tregs. Both preclinical and GMP grades are produced in a dedicated GMP facility.
TGF‑β1, a member of the TGF‑β superfamily, regulates cell differentiation, proliferation, and apoptosis and is secreted by many immune cells, including T cells, B cells, macrophages, and monocytes. In cell and gene therapy, it is used to expand iPSCs, ESCs, MSCs, and Tregs.
CellGenix® rh TGF‑β1 is produced in a human amniocyte cell line (CAP®), enabling authentic human post‑translational modifications that cannot be achieved with bacterial expression systems.
EGF
CellGenix® Recombinant Human EGF (rh EGF) is an animal component–free growth factor that promotes expansion of mesenchymal stem cells (MSCs) and supports differentiation of ESC‑ and iPSC‑derived hepatoblasts. Both preclinical and GMP grades are produced in a dedicated animal-free GMP facility.
EGF drives cell growth, proliferation, and differentiation and is present in various body fluids. In cell and gene therapy, it is used to expand bone marrow– and adipose-derived MSCs and generate stem cell–derived hepatocytes.
