Protein A Membranes: Optimized Process Performance and Productivity
As the biopharmaceutical industry continues to grow and offers new therapies, it must also address the following four important pillars: Cost reduction, high flexibility, fast time to market and increased quality/process stability. Intensify/connected bioproduction is a hot topic in our industry as it addresses these pain points by increasing productivity and efficiency, reducing space requirements, and being cost-effective.
An intensification of the mAb capture step can be achieved by Rapid Cycling Chromatography (RCC). The implementation of RCC requires the coordinated interaction of a specially designed membrane, suitable devices and a supporting skid technology: We have developed a new 'convecdiff' base membrane that offers high mass transfer and high permeability, thus overcoming the limitations of diffusible and purely convective materials for RCC. By exploiting the full life cycle within low batch processes (e.g. for experimental material) and by miniaturising large scale manufacturing processes, this new 'convecdiff' membrane offers new possibilities for the production of clinical and commercial drug substances.
Key Learning Objectives
- Learn more about the new 'convecdiff' base membrane, which enables enhanced mAb capture using Rapid Cycling Chromatography (RCC)
- Gain more insight into the concept of RCC ('convecdiff' membrane, scalable device portfolio, optimized skid)
- Learn how short cycle time, caustic stability, low pressure drops and low membrane fouling propensity ensure optimal process performance
Meet Our Experts
Ricarda A. Busse
PhD, MBA, Product Manager Chromatography Consumables, Sartorius
Dr. Ricarda A. Busse joined Sartorius in February 2018 as a Product Manager for Membrane Chromatography. She has a PhD in biology | biochemistry from the Georg-August University of Goettingen. She also holds an MBA from the European Fernhochschule Hamburg in General Management, where she specialized in digital and international marketing. She has 8+ years of experience in the biotechnology and bioprocessing industry. Prior to joining Sartorius, she worked as Product and Marketing Manager for affinity chromatography solutions used for recombinant proteins at IBA Lifesciences. During her time as a doctoral candidate at the Max Planck Institute of Biophysical Chemistry, Geottingen, she worked on upstream and downstream process optimization of recombinant proteins from bacterial,
Ganesh Kumar
MS, Integrated Solutions Manager, Sartorius
Ganesh started at Sartorius in 2016 as a Process Engineer | Consultant and was one of the key contributors to the development of the conceptual design platform to design end-to-end process platforms in SU facilities. Today he fills the role of Integrated Solutions Manager. As part of the Integrated Solutions team at Sartorius,
he actively works with clients to conceptualize, design, and deliver process solutions and platforms at clinical | commercial manufacturing stage for production of protein-based and cell | gene-based therapies. He holds a Master of Science in Bioprocess Engineering from Technical University Hamburg-Harburg, Germany. Ganesh started his career at Lonza, Singapore, where he was actively involved in the tech transfer, validation, and large-scale commercial manufacturing of blockbuster mAbs. Over the years, he has actively collaborated|led projects on process positioning, acquisitions, building the technical platform, solution packages and establishing strategic customer collaborations for process intensification. He has over nine years of experience in the biopharmaceutical industry, both as an end-user and a solution provider. He is based in Göttingen, Germany.