Exploring the SARS-CoV-2 Outer Cell Surface: Lessons in Innate and Adaptive Immunity
Overview
SARS-CoV-2 nucleocapsid (N) protein is highly expressed during infection, inducing strong antibody and T-cell responses. Until recently, scientists thought that the N protein was exclusively localized intracellularly.
In this webinar, Alberto Lopez-Munoz will discuss how bio-[layer interferometry on the Octet® platform facilitated the molecular mechanism characterization behind N protein surface binding, uncovering its functions in host innate immunity to SARS-CoV-2.
Watch Time: 48 minutes
Key webinar discussion topics include:
- Cell-surface SARS-CoV-2 N protein expression characterization
- Glycosaminoglycans as mediators of surface N protein binding
- Extracellular N protein-mediated immunomodulation
Webinar Speaker
Alberto D. Lopez-Munoz, PhD, MSc
Postdoctoral Fellow, Cellular Biology Section, Laboratory of Viral Diseases
National Institute of Allergy and Infectious Diseases; National Institutes of Health
