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Shedding Light On the Dark Art Of Bioprocess Scaling
Establish a Successful Transition Between Manufacturing Scales
A unique feature of the bioprocessing industry is that process development is carried out on a significantly smaller scale than during clinical or commercial manufacturing. The resources used to manufacture biologics (facilities, trained personnel, cells, media components, consumables, and instrumentation) are expensive and require significant expertise to handle. In order to limit development costs, increase design space understanding, and maximize efficiency, upstream bioprocesses are typically developed and optimized at the smallest scale possible.