Application Note: Plastic Resin, Titration Standards and the Importance of Moisture Analysis when Manufacturing Medical Devices

An important variable to monitor during the production of plastic medical device parts is moisture content. Resin manufacturers provide specification sheets detailing maximum allowable water ratios and drying times/temperatures; however, these general recommendations do not factor in variables such as resin storage or drying unit efficiency.  

When resin is not given enough time to dry, it can fail to meet requirements. Molding wet resin can result in splay marks, streaking, fogging or improper mechanical properties. When it comes to medical equipment, such flaws cannot be allowed.  

Download this informative application note and learn about how the Sartorius Mark 3 High-Performance Moisture Analyzer correlates with Karl Fischer titration standards for a number of plastic resins commonly used in medical device manufacture.

Commonly Asked Questions:  

  • How does loss on drying differ from Karl Fischer titration? 
    • The Karl Fischer titration method determines only sample’s water content. This may include water from crystallization and surface absorption but does not factor in any other substances. Loss on drying also factors in the presence of volatile impurities.  
  • What is the optimal method for testing moisture content in plastic resins?
    • Gravimetric moisture analyzers are most often used to determine moisture content in plastic resin. 

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