Ultrapure Water as a Key Component for Accurate Liquid Chromatography Results

Author: Sartorius | Last updated: June 2025

Ultrapure Water as a Key Component for Enhanced LCMS Results

Resource overview

In Liquid Chromatography coupled with Mass Spectrometry (LCMS) applications, the quality of water is crucial. Ultrapure water, adhering to ASTM Type I specifications, is essential for mobile phase preparation, sample dilution, reagent preparation, and instrument cleaning. 

Water impurities such as particulates, bacteria, and ions can compromise chromatographic performance, leading to poor data quality, overlapping peaks, ghost peaks, and column damage. The freshly produced ultrapure water from our Arium® Mini UV (Arium® Water) systems can help scientists overcome water impurities and unlock the full potential of LCMS analysis.

Explore how in-house water purification systems contribute to the consistency and integrity of sensitive analytical workflows.
 

Key takeaways:

  1. Understand the critical impact of water purity on LCMS accuracy and system performance
  2. Learn how contaminants in DI or bottled water can introduce noise, distort peaks, and compromise results
  3. Gain insights into the advantages of using freshly produced ultrapure water from in-house systems like the Arium® Mini UV
  4. Explore how water quality influences chromatographic baselines, peak shapes, and data reproducibility
  5. Discover the long-term cost benefits of switching from bottled water to an in-house ultrapure water system
     

Resource details:

  • Document type: Article
  • Page count: 2
  • Read time: 4 minutes

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