Integrating Live-Cell Analysis for targeted In Vitro LNP Screening
Author: Nicola Bevan3, Thibaut Ben Chimol1, Marine Fenat1, Claire Guéguen1, Kevin Lance 2, Jasmine Trigg3, Ben Knappett4 and Catriona Thomson3 1Sartorius Polyplus, Illkirch-Graffenstaden, France 2Unchained Labs, US 3Sartorius, Royston, UK 4Unchained Labs, Royston, UK
Corresponding author: claire.Gueguen@sartorius.com
Last Updated: February 2026
Overview
This poster demonstrates how live‑cell analysis accelerates targeted in vitro LNP screening. Using the Incucyte® live cell analysis system, researchers quantify transfection efficiency, viability and cell health across diverse cell types, including HEK‑293, epithelial, macrophage and T cells. The workflow rapidly identifies high‑performing LNP formulations and supports optimization for enhanced mRNA delivery and selective organ‑targeting.
Resource Details:
- Document Type: Poster
- Page Count: 1
- Read Time: 5 minutes
Key Takeaways
- Live‑cell analysis enables rapid, targeted in vitro screening of LNP formulations, providing real‑time insight into transfection and cell health.
- Cell‑by‑Cell imaging quantifies GFP expression across diverse cell types.
- Several LNPs outperform SM‑102 while maintaining viability.
- Workflow accelerates identification of high‑performing LNPs for optimized mRNA delivery.