Infographic: Assessing Mitochondrial Health in Oncology
Last Updated: April 2022
Overview
Mitochondria are maternally inherited, cytoplasmic organelles that are critical for normal cell function and health. They also play a pivotal role in cancer cells and are important for tumor initiation, maintenance and growth.
Mitochondrial cytosolic adenosine triphosphate (ATP) production provides a more efficient energy source over glycolysis, allowing tumor cells to survive tough nutrient environments. Therefore, it is important to understand the complex relationship between cancer cells and mitochondria, especially when evaluating how metabolic symbiosis promotes drug resistance.
- Document type: Infographic
- Page count: 1
- Read time: 3 minutes
Key Takeaways
Download this infographic to learn about:
- Mitochondrial membrane potential (MMP) workflow
- Cytosolic adenosine triphosphate (ATP) assay workflow
- Kinetic live-cell image acquisition and analysis
Fig. 1 The Incuycte® ATP assay is used to evaluate the effect of a glutaminase inhibitor (CB-839) on cytosolic ATP levels in triple-negative breast cancer (HCC38) cells co-cultured with fibroblasts (CCD14086SK) as a model of stromal-tumor cell nutrient exchange
