On-Demand Webinar: Quantifying T cell Exhaustion: An Insight into BiTE antibodies and CAR-T cells for Improved Therapeutics
Overview
T cell exhaustion is recognized as a major challenge in the development of immuno-oncology therapies. It is a broad term used to describe the loss of effector function due to chronic antigen exposure, and commonly occurs within the tumor microenvironment, impairing the T cells ability to effectively eradicate cancerous cells.
The development of tumor specific immunotherapies focuses on overcoming this exhausted phenotype of T cells, to allow targeted killing of the tumor.
The webinar includes the following topics:
- An explanation of how Bispecific T cell Engager (BiTE) antibodies in an immune cell killing assay affect T cell exhaustion
- Consideration of the influence of target cells on CAR-T cell exhaustion
- A discussion on use of the iQue® High-Throughput Screening Cytometry Platform, to quantify T cell exhaustion phenotypes and cytokine release
Webinar Speaker
Lauren Kelsey
Lauren Kelsey was a Scientist in the iQue® applications group, part of the European based BioAnalytics at Sartorius, where she was involved in the research and development of novel applications. Lauren’s efforts focused on the iQue® High-Throughput Screening Cytometry Platform, where she supported a number of the immuno-oncology campaigns.
Lauren obtained a degree in Biology at the University of Bath and then completed a masters in Regenerative Medicine, where she studied mouse pancreatic and liver development.
