Building Better 3D Cell Models: Advances in Organoid Development, Automation, and Biomedical Research

Overview

Biomedical research is being transformed by the rapid evolution of organoid technology. 3D cell models are becoming increasingly sophisticated.  So simply building them, is not sufficient. Generating robust, reproducible models which can be deployed at scale is crucial.

Three researchers working across organoid development, quantitative analysis, and disease modeling, will meet to discuss the approaches that are moving organoid technology forward.

This webinar will include details of:

• Approaches for building and applying organoid systems, in studying human development, neurodegenerative diseases and aging.
• How advances in differentiation, characterization, and automation are improving the development and reproducibility of 3D cell models.
• How translational research and drug discovery is being expanded by next-generation 3D cell models.
• Answers to Live Audience Questions.

Register Here

Dr Karim Ben M’Barek

i-Stem, Corbeil-Essonnes, France

Karim Ben M’Barek has been devoted for more than 14 years to advancing stem cell–based therapies for retinal dystrophies, including retinitis pigmentosa and age-related macular degeneration. His research focuses on leveraging human pluripotent stem cells (hiPSCs and hESCs) alongside tissue bioengineering to develop innovative regenerative strategies for vision restoration. In parallel, he has designed and implemented novel surgical techniques and medical devices to enable the successful engraftment of complex retinal tissues, contributing to significant progress in ocular regenerative medicine.

More recently, M’Barek has been harnessing hiPSC technology to model genetic retinal diseases in vitro using both two-dimensional systems and three-dimensional retinal organoids. To support these efforts, he has developed automated and scalable processes that enhance the reproducibility and robustness of cell manufacturing, facilitating the translation of these models into research and therapeutic applications.

Dr Fred Gage

Salk Institute for Biological Sciences, La Jolla, CA

Fred Gage is the Adler Professor in the Laboratory of Genetics and immediate past president of the Salk Institute, as well as an adjunct professor at the University of California, San Diego. He received his Ph.D. from Johns Hopkins University. Dr. Gage’s work concentrates on the adult central nervous system and unexpected plasticity and adaptability to environmental stimulation that remains throughout the life of all mammals. In addition, he models human neurological and psychiatric disease in vitro using human stem cells. His lab also studies the genomic mosaicism that exists in the brain as a result of mobile elements that are active during neurogenesis.

Gage is a fellow of the American Association for the Advancement of Science and a member of the National Academy of Sciences and the National Academy of Medicine, the American Philosophical Society, the European Molecular Biology Organization, and the American Academy of Arts and Sciences. He served as president of the Society for Neuroscience in 2002 and of the International Society for Stem Cell Research in 2012.

Dr Prisca Liberali

ETH Zurich, Zurich, Switzerland

Prisca Liberali is a pioneer of organoid-based screening technology and a leader in decoding the principles of tissue self-organization and regeneration. Her development of the first high-content phenotypic screening platform in organoids transformed 3D tissue systems into quantitative models for biology and drug discovery. Her work is now driving a new paradigm in precision regenerative medicine, linking single-cell variability, tissue mechanics, and patient-specific drug responses in human organoid systems.