Ex Vivo Cell Therapy Expansion has Evolved
Advanced protein-based soluble activation enhances your next immunotherapy.
Powered by the proprietary NanoSpark® platform, this innovative soluble activation technology geometrically orients activation antibodies to trigger optimal receptor clustering-driving robust immune cell activation while reducing overstimulation risks. The result? Healthier cells, higher yields, and enhanced therapeutic performance.
Why Choose NanoSpark®
- Soluble, Protein-Based, GMP-Ready: Streamlined formulation for clinical readiness no beads, no synthetic residues
- Superior Cell Expansion & Phenotype: Supports growth of functional, less-exhausted immune cells for improved efficacy
- Enhanced Safety Profile: Reduces regulatory and safety concerns by limiting particles in the final products and not overstimulating CD4+ T cells
- Automation-Friendly: Designed for closed, automated manufacturing platforms—ideal for scalable production
Explore Solutions by Application
Learn more about how NanoSpark® activation reagents can improve the yield and functionality of immune cells in your therapy development processes.
Activate and Expand CAR-T Cells, Targeting CD8+ Expansion for High Stemness and Therapeutical Efficacy
Soluble, protein-based, bead-free, culture-ready reagent for ex vivo activation and expansion of human T cells that favors stem-like CD8+ T cell production maximising therapeutic potential of T cell therapies. For research use only.
- Soluble
- All protein-based
- No magnetic or bead-based components
- Anti-CD3/CD28 based
- High total & stem-like CD8+ T cell production
Expand and Activate CAR-T cells, Targeting CD8+ Expansion for High Stemness and Therapeutical Efficacy
Soluble, protein-based, bead-free, culture-ready reagent for ex vivo activation and expansion of human T cells that favors stemlike CD8+ T cell production maximising therapeutic potential of T cell therapies. For research and ex vivo cell processing only.
- Soluble format
All protein-based
No magnetic components
High total & stem-like CD8+ T cell production
Anti-CD3/CD28 based
Manufactured in accordance with relevant GMP guidelines
Feeder Free, High Quality NK Cell Activation and Expansion for NK Cell Therapy Programs
The NanoSpark® GROW-NK Activator is a culture-ready, feeder-free reagent for in vitro activation and expansion of human NK cells. It uses anti-NKp46 & anti-CD2 mAbs on the NanoSpark® platform to activate and expand NK cells in an easy-to-use, feeder-free manner.
- Soluble, all protein-based
- No magnetic or bead-based components
- Anti-NKp46/CD2 based
- Feeder cell-free NK expansion with high viability and cytotoxicity
- GMP available in 2026
FAQs - NanoSpark® GROW-NK
The NanoSpark® nanoparticle is a synthetic, monomeric protein of non-human sequence that self-aggregates to generate a protein scaffold. This nanoparticle then binds and displays anti-CD2 and anti-NKp46 antibodies, in a defined mosaic, clustering them in an optimal orientation and spatial distancing for high-efficacy NK cell activation.
The Nanospark® nanoparticle is about 20 nm in diameter and around 600 kDa alone, and as the full GROW-NK reagent is increased in size.
No, the NanoSpark® GROW-NK Soluble Activator is a culture-ready, feeder-free reagent for in vitro activation and expansion of human NK cells. There is no other product like it. It’s simple, easy-to-use, and removes the need for costly, laborious, and risky feeder cells – that could introduce clinical risks to the process by contaminating cell therapies with cancer cells that could also harbour human pathogens.
FAQs - NanoSpark® STEM-T
The NanoSpark® nanoparticle is a synthetic, monomeric protein of non-human sequence that self-aggregates to generate a protein scaffold. This nanoparticle then binds and displays anti-CD3 and anti-CD28 antibodies, in a defined mosaic, clustering them in an optimal orientation and spatial distancing for high-efficacy T cell activation.
The NanoSpark® nanoparticle is about 20 nm in diameter and around 600 kDa alone, and as the full STEM-T reagent is increased in size.
We offer both RUO and GMP-grade to allow for a seamless transition from preclinical development to the clinical stage. Both product grades are manufactured under the high-quality conditions and in dedicated facilities, using identical production steps and expression systems. This ensures an equal product quality and performance.
The difference between both quality levels is that we offer more comprehensive quality control (QC) testing, including tighter specifications and documentation for our GMP products. Our preclinical grade products offer a cost-efficient alternative for the early development phase when regulatory support and quality of raw materials have a lower priority and access to GMP-relevant documentation is not yet required.
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