Hematopoietic Stem Cells (HSCs)
Hematopoietic stem cells (HSCs) are characterized by the capacity for self-renewal, multipotentiality and differentiation into an entire hematopoietic system, i.e., into any and all different hematopoietic cell types including all immune cells. Established clinical applications are focused on transplantation of healthy allogeneic donor hematopoietic cells after high-dose chemotherapy for lymphoma, leukemia, and certain immune-deficiency diseases. Recent applications target the use of genetic modifications of autologous HSCs.
To ensure a seamless transition from preclinical development to commercial manufacturing, we offer CellGenix® cytokines and growth factors both in GMP and preclinical grade.
Our GMP cytokines are provided with documented evidence of purity, potency, consistency and stability. In combination with our expert regulatory and technical support this will help simplify your raw material qualification and validation efforts.
CellGenix® GMP recombinant cytokines are produced following all applicable GMP guidelines and allow for the safe use in accordance with USP Chapter <1043>, Ph. Eur. General Chapter 5.2.12 and ISO 20399:2022.
Test Growth Factor and Cytokines Samples for HSC Cells
Samples for cell and gene therapy as well as regenerative medicine.
HSC Growth Factors and Cytokines | ||
|---|---|---|
Flt-3L | More Info | Visit eShop |
SCF | More Info | Visit eShop |
TPO | ||
IL-3 | More Info | Visit eShop |
IL-6 | More Info | Visit eShop |
Flt-3L
CellGenix® Recombinant Human FMS-like Tyrosine Kinase 3 Ligand (Flt-3L) i is an animal component–free cytokine that supports proliferation of hematopoietic stem cells (HSCs). Both preclinical and GMP grades are produced in a dedicated animal-free GMP facility.
Flt‑3L regulates proliferation and differentiation of multiple blood cell progenitors and is used in cell and gene therapy for ex vivo expansion of HSCs used for transplantation.
SCF
CellGenix® Recombinant Human Stem Cell Factor (rh SCF) is an animal component–free cytokine that supports survival and differentiation of hematopoietic stem and progenitor cells, drives cord blood–derived CD34⁺ cells toward NK cells, and is used to differentiate ESCs and iPSCs into megakaryocytes and T cells. Both preclinical and GMP grades are produced in a dedicated animal-free GMP facility.
SCF, produced by fibroblasts and endothelial cells, is essential for hematopoiesis, spermatogenesis, and melanogenesis and is used in cell and gene therapy of HSCs used for transplantation.
TPO
CellGenix® Recombinant Human Thrombopoietin (rh TPO) is an animal component–free cytokine that supports self‑renewal and maintenance of hematopoietic stem cells (HSCs), drives their differentiation into NK cells, and promotes ESC/iPSC differentiation into megakaryocytes. Both preclinical and GMP grades are produced in a dedicated animal-free GMP facility.
TPO is a liver- and kidney-derived glycoprotein hormone that regulates platelet production by stimulating megakaryocyte formation. In cell and gene therapy, it is used for ex vivo expansion and differentiation of HSCs.
IL-3
CellGenix® Recombinant Human IL‑3 (rh IL‑3) is an animal component–free cytokine that reliably stimulates proliferation of hematopoietic stem cells (HSCs/CD34⁺). Both preclinical and GMP grades are produced in a dedicated animal-free GMP facility.
IL‑3, primarily produced by activated T cells, mediates immune responses by driving HSC proliferation into major blood lineages. In cell and gene therapy, IL‑3 is used for ex vivo expansion of HSCs.
IL-6
CellGenix® Recombinant Human IL‑6 (rh IL‑6) is an animal component–free cytokine that drives maturation of immature dendritic cells (DCs) and promotes proliferation of cord blood–derived HSCs (CD133⁺). Both preclinical and GMP grades are produced in a dedicated animal-free GMP facility.
IL‑6 is a multifunctional cytokine with pro‑ and anti‑inflammatory roles, regulating acute phase responses, hematopoiesis, bone metabolism, cancer progression, and immunity. Produced mainly by T cells, monocytes, and macrophages, it is used in cell and gene therapy for ex vivo DC maturation and HSC expansion.
