Hematopoietic Stem Cells (HSCs)
Hematopoietic stem cells (HSCs) are characterized by the capacity for self-renewal, multipotentiality and differentiation into an entire hematopoietic system, i.e., into any and all different hematopoietic cell types including all immune cells. Established clinical applications are focused on transplantation of healthy allogeneic donor hematopoietic cells after high-dose chemotherapy for lymphoma, leukemia, and certain immune-deficiency diseases. Recent applications target the use of genetic modifications of autologous HSCs.
To ensure a seamless transition from preclinical development to commercial manufacturing, we offer CellGenix® cytokines and growth factors both in GMP and preclinical grade.
Our GMP cytokines are provided with documented evidence of purity, potency, consistency and stability. In combination with our expert regulatory and technical support this will help simplify your raw material qualification and validation efforts.
CellGenix® GMP recombinant cytokines are produced following all applicable GMP guidelines and allow for the safe use in accordance with USP Chapter <1043>, Ph. Eur. General Chapter 5.2.12 and ISO 20399:2022.
Test Growth Factor and Cytokines Samples for HSC Cells
Samples for cell and gene therapy as well as regenerative medicine.
HSC Growth Factors and Cytokines | ||
|---|---|---|
Flt-3L | More Info | Visit eShop |
SCF | More Info | Visit eShop |
TPO | ||
IL-3 | More Info | Visit eShop |
IL-6 | More Info | Visit eShop |
Flt-3L
CellGenix® Recombinant Human FMS-like Tyrosine Kinase 3 Ligand (Flt-3L) is an animal-derived component-free product. It reliably supports the proliferation of hematopoietic stem cells (HSCs). CellGenix® rh Flt-3L preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
General Information
Flt-3L is a cytokine that regulates proliferation and differentiation of various blood cell progenitors.
Flt-3L is used in the cell and gene therapy space for the ex vivo expansion of HSCs that are used for transplantation.
SCF
CellGenix® Recombinant Human Stem Cell Factor (SCF) is an animal-derived component-free product. It reliably supports survival and differentiation of hematopoietic stem cells (HSCs) and progenitor cells as well as the differentiation of cord blood-derived CD34+ cells into natural killer cells (NK cells). It is also used to differentiate embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into megakaryocytes and T cells. CellGenix® rh SCF preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
General Information
SCF is a cytokine that is produced by fibroblasts and endothelial cells. It plays an important role in hematopoiesis, spermatogenesis and melanogenesis.
SCF is used in the cell and gene therapy space for the expansion of HSCs that are used for transplantation.
TPO
CellGenix® Recombinant Human Thrombopoietin (TPO) is an animal-derived component-free product. It reliably supports the self-renewal and maintenance of hematopoietic stem cells (HSCs) as well as the differentiation of HSCs into natural killer cells (NK cells). It is also used to differentiate embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into megakaryocytes. CellGenix® rh TPO preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
General Information
TPO is a glycoprotein hormone produced by the liver and kidney. It regulates the production of platelets and stimulates the production and differentiation of megakaryocytes.
TPO is used in the cell and gene therapy space for the ex vivo expansion and differentiation of HSCs.
IL-3
CellGenix® Recombinant Human Interleukin-3 (IL-3) is an animal-derived component-free product. It reliably stimulates the proliferation of hematopoietic stem cells (HSCs/CD34+ cells). CellGenix® rh IL-3 preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
General Information
IL-3 is a cytokine which acts as a mediator in the body’s natural immune system. It amongst others strengthens the immune response by stimulating the proliferation of HSCs into the major blood cell types. IL-3 is produced primarily by activated T cells.
IL-3 is used in the cell and gene therapy space for the ex vivo expansion of HSCs.
IL-6
CellGenix® Recombinant Human Interleukin-6 (IL-6) is an animal-derived component-free product. It reliably stimulates the maturation of immature to mature dendritic cells (DCs) and promotes the proliferation of cord blood derived hematopoietic stem cells (HSCs/CD133+ cells). CellGenix® rh IL-6 preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
General Information
IL-6 is a multifunctional cytokine that acts both pro-inflammatory and anti-inflammatory. It regulates acute phase responses, inflammatory reactions, hematopoiesis, bone metabolism, cancer progression and immune responses. It is produced primarily by T cells, monocytes and macrophages.
IL-6 is used in the cell and gene therapy space for the ex vivo maturation of immature DCs and proliferation of HSCs.
