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High-throughput upstream process development for CHO cells using Ambr®️ 250 Multi-Parallel Bioreactor System

Process development is driven by designing processes for a wide range of expression systems in order to establish the appropriate process parameters that will result in successful scale up and robust cGMP manufacturing.

In this webinar, Olga Morejón Zayas, Head of Process Development at 3P Biopharmaceuticals, will present her work with Ambr® 250 on three experimental packages used to define the optimal process parameter to support high cell density culture of CHO DG44 cells to improve productivity and scalability.

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Morejón will present evaluation data on media and feed screening, optimization of feed strategies and optimization of process parameters. The results will highlight the value of the Ambr® 250 in the optimization of high cell density cultures and the relevance of the system for scalability and consistency of results.

Key Learning Objectives:

  1. Gain overview of recent developments on the Ambr250 ht for upstream process development

  2. Learn how to use the Ambr250 ht and integrated at-line metabolite analyzers for rapid media and feed screening, followed by feeding strategy and process parameter optimization, all in a small-scale, automated high-throughput approach

  3. Hear about how 3P Biopharmaceuticals was able to increase productivity, reaching >15g/L of product, by intensifying an optimized CHO process

Meet Our Experts

Olga Morejón Zayas

Head of Process Development, 3P Biopharmaceuticals

Olga joined 3P Biopharmaceuticals in 2012 and is responsible for a multidisciplinary team working in more than 40 project of process development, process optimization, technical transfer and process characterization. She is part of a team that designs, develops, scale up and validate the process to produce different recombinant proteins and monoclonal antibodies that are currently in late stage of clinical trials and commercial phase.

Olga has a Degree in Chemical Engineering and Master in Biotechnology Process Engineering both obtained in the Institute of Technology “José A. Echeverría”, Havana, Cuba. She has more than 25 years of experience in design, scale-up, optimization and validation of biotechnology processes

Lidia Garcia

Application specialist CCT: Field Application specialist - Cell Culture Technologies

Lidia joined Sartorius in January 2019 and is an Application Specialist in Cell Culture Technologies group, responsible for Spain, Portugal & Italy. Previously she worked for 20 years at Zoetis Manufacturing & Research Spain, S.L. at the R&D Department as a Principal Scientist and has wide ranging expertise in animal cell biotechnology, biochemical engineering, process scale up, upstream and downstream processing, microcarrier technology and virology.

Lidia has a Bachelor of Science degree in Biology and a Ph.D. in Cell Biology both obtained from the Autonomous University of Barcelona (Spain) and is a member of the European Society for Animal Cell Technology (ESACT)

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