The Fundamentals of Viral Vector Upstream Processing (VV-USP)
This course will provide you with the necessary scientific background on viral vectors, giving an overview of the essential steps in the upstream processing of vectors, including analytical tools, process development considerations and manufacturing strategies, focusing primarily on AAV, LV and AdV. It will also offer insight into the market and trends as well as industry needs and challenges.
It includes:
- Mix of self-paced and instructional units with 4 - 5 hours of learning per week (35 – 40 hours in total) over 2.5 months
- Interactive collaborative platform to facilitate knowledge exchange
- Limited synchronous activities allow participation from across the globe
- 98% recommendation rate from previous learners
Duration:
45 - 50 h
Self-Learning Program Available From:
Registration is open. Register your interest by filling out the form at the bottom of this page.
Lab managers, team leads, researchers, engineers and scientists with expertise in bioprocessing and basic knowledge of gene therapy. Fluent English is essential for optimal learning.
Upon completion of this course, you will be able to:
- Understand various forms of viral vectors and their application
- Differentiate between various cell lines used and understand their testing and regulatory requirements
- Explain upstream process development considerations (parameters, cell line, media, scale-up) and tools used
- Discuss production strategy, modes, workflows along with process controls and analytics
This online course consists of both self-paced and collaborative learning units, allowing you to fit in learning around your work schedule. Each chapter includes live discussions, assignments, access to experts and Q&A sessions, using an interactive and collaborative platform to facilitate knowledge exchange between participants.
Focus Topics & Agenda
How is the Sartorius Academy’s Fundamental of Viral Vector Upstream Processing course structured?
Introduction to Viral Vectors |
Cell Line Development and Cell Banking |
Process Development and Manufacturing |
Analytical Methods |
Learning Modules
Duration: 2.0 weeks
- Viral vector market, trends and opportunities
- Description of the Adeno-associated virus, Lentivirus and Adenovirus
- The basics of the viral vector manufacturing process
Duration: 2.0 weeks
- Review of typical cell line used for viral vector production
- Basics about transient production (transfection, infection), and stable production
- Introduction to cell banking, virus banking, testing required and regulatory considerations
Duration: 2.0 weeks
- Overview of AAV, LV and AdV upstream workflows
- Review of key process development considerations: cell culture optimization, adherent vs suspension production, process optimization and scale-up
- Review the different production strategies for viral vectors
- Process controls and analytics during production
Duration: 2.0 weeks
- Where and why analytics are used in viral vector processes
- Introduction to the commonly used analytical solutions
- Considerations and challenges to select the right analytical methods
