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Expediting Lentiviral Vector Development with Automated Bioreactors and Design of Experiments
Developing new LV bioprocesses is slow due to the difficulty in establishing optimal values for critical process parameters and the time required to run analytical assays. This project design allowed for rapid deployment of processes and scale-up to a 50 L Biostat STR® through:
- Accurate, data-driven product estimates to speed up development timelines
- The application of design of experiments (DOE) in combination with automated multi-way bioreactors (Ambr® 15)